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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
Nordström E, Eriksson F, Sigvardson J, Johannesson M, Kasrayan A, Jones-Kostalla M, Appelkvist P, Söderberg L, Nygren P, Blom M, Rachalski A, Nordenankar K, Zachrisson O, Amandius E, Osswald G, Moge M, Ingelsson M, Bergström J, Lannfelt L, Möller C, Giorgetti M, Fälting J. Nordström E, et al. Among authors: sigvardson j. Neurobiol Dis. 2021 Dec;161:105543. doi: 10.1016/j.nbd.2021.105543. Epub 2021 Nov 1. Neurobiol Dis. 2021. PMID: 34737044 Free article.
Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.
Rostami J, Holmqvist S, Lindström V, Sigvardson J, Westermark GT, Ingelsson M, Bergström J, Roybon L, Erlandsson A. Rostami J, et al. Among authors: sigvardson j. J Neurosci. 2017 Dec 6;37(49):11835-11853. doi: 10.1523/JNEUROSCI.0983-17.2017. Epub 2017 Oct 31. J Neurosci. 2017. PMID: 29089438 Free PMC article.
Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways.
Almandoz-Gil L, Welander H, Ihse E, Khoonsari PE, Musunuri S, Lendel C, Sigvardson J, Karlsson M, Ingelsson M, Kultima K, Bergström J. Almandoz-Gil L, et al. Among authors: sigvardson j. Free Radic Biol Med. 2017 Sep;110:421-431. doi: 10.1016/j.freeradbiomed.2017.07.004. Epub 2017 Jul 6. Free Radic Biol Med. 2017. PMID: 28690195 Free article.
Corrigendum to "Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways" [Free Rad. Biol. Med. (2017) 421-431].
Almandoz-Gil L, Welander H, Ihse E, Khoonsari PE, Musunuri S, Lendel C, Sigvardson J, Karlsson M, Ingelsson M, Kultima K, Bergström J. Almandoz-Gil L, et al. Among authors: sigvardson j. Free Radic Biol Med. 2018 Mar;117:258. doi: 10.1016/j.freeradbiomed.2018.02.007. Epub 2018 Feb 16. Free Radic Biol Med. 2018. PMID: 29455934 Free article. No abstract available.