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ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease.
Neurobiol Dis. 2021 Dec;161:105543. doi: 10.1016/j.nbd.2021.105543. Epub 2021 Nov 1.
Neurobiol Dis. 2021.
PMID: 34737044
Free article.
Mapping of Surface-Exposed Epitopes of In Vitro and In Vivo Aggregated Species of Alpha-Synuclein.
Almandoz-Gil L, Lindström V, Sigvardson J, Kahle PJ, Lannfelt L, Ingelsson M, Bergström J.
Almandoz-Gil L, et al. Among authors: sigvardson j.
Cell Mol Neurobiol. 2017 Oct;37(7):1217-1226. doi: 10.1007/s10571-016-0454-0. Epub 2016 Dec 27.
Cell Mol Neurobiol. 2017.
PMID: 28028735
Free PMC article.
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Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage.
Lindström V, Gustafsson G, Sanders LH, Howlett EH, Sigvardson J, Kasrayan A, Ingelsson M, Bergström J, Erlandsson A.
Lindström V, et al. Among authors: sigvardson j.
Mol Cell Neurosci. 2017 Jul;82:143-156. doi: 10.1016/j.mcn.2017.04.009. Epub 2017 Apr 24.
Mol Cell Neurosci. 2017.
PMID: 28450268
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Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes.
Rostami J, Holmqvist S, Lindström V, Sigvardson J, Westermark GT, Ingelsson M, Bergström J, Roybon L, Erlandsson A.
Rostami J, et al. Among authors: sigvardson j.
J Neurosci. 2017 Dec 6;37(49):11835-11853. doi: 10.1523/JNEUROSCI.0983-17.2017. Epub 2017 Oct 31.
J Neurosci. 2017.
PMID: 29089438
Free PMC article.
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Region-Specific Effects of Immunotherapy With Antibodies Targeting α-synuclein in a Transgenic Model of Synucleinopathy.
Kallab M, Herrera-Vaquero M, Johannesson M, Eriksson F, Sigvardson J, Poewe W, Wenning GK, Nordström E, Stefanova N.
Kallab M, et al. Among authors: sigvardson j.
Front Neurosci. 2018 Jul 4;12:452. doi: 10.3389/fnins.2018.00452. eCollection 2018.
Front Neurosci. 2018.
PMID: 30022929
Free PMC article.
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Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways.
Almandoz-Gil L, Welander H, Ihse E, Khoonsari PE, Musunuri S, Lendel C, Sigvardson J, Karlsson M, Ingelsson M, Kultima K, Bergström J.
Almandoz-Gil L, et al. Among authors: sigvardson j.
Free Radic Biol Med. 2017 Sep;110:421-431. doi: 10.1016/j.freeradbiomed.2017.07.004. Epub 2017 Jul 6.
Free Radic Biol Med. 2017.
PMID: 28690195
Free article.
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Corrigendum to "Low molar excess of 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote oligomerization of alpha-synuclein through different pathways" [Free Rad. Biol. Med. (2017) 421-431].
Almandoz-Gil L, Welander H, Ihse E, Khoonsari PE, Musunuri S, Lendel C, Sigvardson J, Karlsson M, Ingelsson M, Kultima K, Bergström J.
Almandoz-Gil L, et al. Among authors: sigvardson j.
Free Radic Biol Med. 2018 Mar;117:258. doi: 10.1016/j.freeradbiomed.2018.02.007. Epub 2018 Feb 16.
Free Radic Biol Med. 2018.
PMID: 29455934
Free article.
No abstract available.
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