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Characterisation of the pharmacodynamic effects of the P2X7 receptor antagonist JNJ-54175446 using an oral dexamphetamine challenge model in healthy males in a randomised, double-blind, placebo-controlled, multiple ascending dose trial.
Recourt K, van der Aart J, Jacobs G, de Kam M, Drevets W, van Nueten L, Kanhai K, Siebenga P, Zuiker R, Ravenstijn P, Timmers M, van Gerven J, de Boer P. Recourt K, et al. Among authors: siebenga p. J Psychopharmacol. 2020 Sep;34(9):1030-1042. doi: 10.1177/0269881120914206. Epub 2020 Apr 4. J Psychopharmacol. 2020. PMID: 32248747 Clinical Trial.
Pharmacological profile of ALKS 7119, an investigational compound evaluated for the treatment of neuropsychiatric disorders, in healthy volunteers.
Dijkstra FM, Zuiker RGJA, Siebenga PS, Leigh-Pemberton RA, Sun L, Manthis JD, de Kam ML, Lin R, von Moltke LL, Rezendes D, van Gerven JMA. Dijkstra FM, et al. Among authors: siebenga ps. Br J Clin Pharmacol. 2022 Jun;88(6):2909-2925. doi: 10.1111/bcp.15229. Epub 2022 Jan 31. Br J Clin Pharmacol. 2022. PMID: 35014069 Free PMC article.
A phase I, randomized, double-blind, placebo-controlled, single- and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX-128, a highly selective Nav 1.8 inhibitor, in healthy adults.
Hijma HJ, van Brummelen EMJ, Siebenga PS, Groeneveld GJ. Hijma HJ, et al. Among authors: siebenga ps. Clin Transl Sci. 2022 Apr;15(4):981-993. doi: 10.1111/cts.13215. Epub 2021 Dec 27. Clin Transl Sci. 2022. PMID: 34958174 Free PMC article. Clinical Trial.
15 results