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Page 1
Therapeutic antibody targeting of individual Notch receptors.
Wu Y, Cain-Hom C, Choy L, Hagenbeek TJ, de Leon GP, Chen Y, Finkle D, Venook R, Wu X, Ridgway J, Schahin-Reed D, Dow GJ, Shelton A, Stawicki S, Watts RJ, Zhang J, Choy R, Howard P, Kadyk L, Yan M, Zha J, Callahan CA, Hymowitz SG, Siebel CW. Wu Y, et al. Among authors: siebel cw. Nature. 2010 Apr 15;464(7291):1052-7. doi: 10.1038/nature08878. Nature. 2010. PMID: 20393564
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression.
Franciosa G, Diluvio G, Gaudio FD, Giuli MV, Palermo R, Grazioli P, Campese AF, Talora C, Bellavia D, D'Amati G, Besharat ZM, Nicoletti C, Siebel CW, Choy L, Rustighi A, Sal GD, Screpanti I, Checquolo S. Franciosa G, et al. Among authors: siebel cw. Oncogene. 2016 Sep 8;35(36):4741-51. doi: 10.1038/onc.2016.5. Epub 2016 Feb 15. Oncogene. 2016. PMID: 26876201 Free PMC article.
NOTCH1 and NOTCH2 regulate epithelial cell proliferation in mouse and human gastric corpus.
Demitrack ES, Gifford GB, Keeley TM, Horita N, Todisco A, Turgeon DK, Siebel CW, Samuelson LC. Demitrack ES, et al. Among authors: siebel cw. Am J Physiol Gastrointest Liver Physiol. 2017 Feb 1;312(2):G133-G144. doi: 10.1152/ajpgi.00325.2016. Epub 2016 Dec 8. Am J Physiol Gastrointest Liver Physiol. 2017. PMID: 27932500 Free PMC article.
Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers.
Choy L, Hagenbeek TJ, Solon M, French D, Finkle D, Shelton A, Venook R, Brauer MJ, Siebel CW. Choy L, et al. Among authors: siebel cw. Cancer Res. 2017 Mar 15;77(6):1439-1452. doi: 10.1158/0008-5472.CAN-16-1022. Epub 2017 Jan 20. Cancer Res. 2017. PMID: 28108512
Notch2 blockade enhances hematopoietic stem cell mobilization and homing.
Wang W, Yu S, Myers J, Wang Y, Xin WW, Albakri M, Xin AW, Li M, Huang AY, Xin W, Siebel CW, Lazarus HM, Zhou L. Wang W, et al. Among authors: siebel cw. Haematologica. 2017 Oct;102(10):1785-1795. doi: 10.3324/haematol.2017.168674. Epub 2017 Jul 20. Haematologica. 2017. PMID: 28729299 Free PMC article.
An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.
Poe JC, Jia W, Su H, Anand S, Rose JJ, Tata PV, Suthers AN, Jones CD, Kuan PF, Vincent BG, Serody JS, Horwitz ME, Ho VT, Pavletic SZ, Hakim FT, Owzar K, Zhang D, Blazar BR, Siebel CW, Chao NJ, Maillard I, Sarantopoulos S. Poe JC, et al. Among authors: siebel cw. Blood. 2017 Nov 9;130(19):2131-2145. doi: 10.1182/blood-2017-05-782466. Epub 2017 Aug 29. Blood. 2017. PMID: 28851699 Free PMC article. Clinical Trial.
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