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GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system.
Asundi J, Zhang C, Donnelly-Roberts D, Solorio JZ, Challagundla M, Connelly C, Boch C, Chen J, Richter M, Maneshi MM, Swensen AM, Lebon L, Schiffmann R, Sanyal S, Sidrauski C, Kolumam G, Baruch A. Asundi J, et al. Among authors: sidrauski c. CNS Neurosci Ther. 2024 Feb;30(2):e14600. doi: 10.1111/cns.14600. CNS Neurosci Ther. 2024. PMID: 38357857 Free PMC article.
eIF2B activator prevents neurological defects caused by a chronic integrated stress response.
Wong YL, LeBon L, Basso AM, Kohlhaas KL, Nikkel AL, Robb HM, Donnelly-Roberts DL, Prakash J, Swensen AM, Rubinstein ND, Krishnan S, McAllister FE, Haste NV, O'Brien JJ, Roy M, Ireland A, Frost JM, Shi L, Riedmaier S, Martin K, Dart MJ, Sidrauski C. Wong YL, et al. Among authors: sidrauski c. Elife. 2019 Jan 9;8:e42940. doi: 10.7554/eLife.42940. Elife. 2019. PMID: 30624206 Free PMC article.
Sugar phosphate activation of the stress sensor eIF2B.
Hao Q, Heo JM, Nocek BP, Hicks KG, Stoll VS, Remarcik C, Hackett S, LeBon L, Jain R, Eaton D, Rutter J, Wong YL, Sidrauski C. Hao Q, et al. Among authors: sidrauski c. Nat Commun. 2021 Jun 8;12(1):3440. doi: 10.1038/s41467-021-23836-z. Nat Commun. 2021. PMID: 34103529 Free PMC article.
Pharmacological brake-release of mRNA translation enhances cognitive memory.
Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Sidrauski C, et al. Elife. 2013 May 28;2:e00498. doi: 10.7554/eLife.00498. Elife. 2013. PMID: 23741617 Free PMC article.
22 results