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Dual-isoform hUBE3A gene transfer improves behavioral and seizure outcomes in Angelman syndrome model mice.
JCI Insight. 2021 Oct 22;6(20):e144712. doi: 10.1172/jci.insight.144712.
JCI Insight. 2021.
PMID: 34676830
Free PMC article.
Recent progress and considerations for AAV gene therapies targeting the central nervous system.
Lykken EA, Shyng C, Edwards RJ, Rozenberg A, Gray SJ.
Lykken EA, et al. Among authors: shyng c.
J Neurodev Disord. 2018 May 18;10(1):16. doi: 10.1186/s11689-018-9234-0.
J Neurodev Disord. 2018.
PMID: 29776328
Free PMC article.
Review.
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Histochemical localization of palmitoyl protein thioesterase-1 activity.
Dearborn JT, Ramachandran S, Shyng C, Lu JY, Thornton J, Hofmann SL, Sands MS.
Dearborn JT, et al. Among authors: shyng c.
Mol Genet Metab. 2016 Feb;117(2):210-6. doi: 10.1016/j.ymgme.2015.11.004. Epub 2015 Nov 11.
Mol Genet Metab. 2016.
PMID: 26597320
Free PMC article.
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Astrocytosis in infantile neuronal ceroid lipofuscinosis: friend or foe?
Shyng C, Sands MS.
Shyng C, et al.
Biochem Soc Trans. 2014 Oct;42(5):1282-5. doi: 10.1042/BST20140188.
Biochem Soc Trans. 2014.
PMID: 25233404
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An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis.
Macauley SL, Wong AM, Shyng C, Augner DP, Dearborn JT, Pearse Y, Roberts MS, Fowler SC, Cooper JD, Watterson DM, Sands MS.
Macauley SL, et al. Among authors: shyng c.
J Neurosci. 2014 Sep 24;34(39):13077-82. doi: 10.1523/JNEUROSCI.2518-14.2014.
J Neurosci. 2014.
PMID: 25253854
Free PMC article.
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Widespread Expression of a Membrane-Tethered Version of the Soluble Lysosomal Enzyme Palmitoyl Protein Thioesterase-1.
Shyng C, Macauley SL, Dearborn JT, Sands MS.
Shyng C, et al.
JIMD Rep. 2017;36:85-92. doi: 10.1007/8904_2017_1. Epub 2017 Feb 18.
JIMD Rep. 2017.
PMID: 28213849
Free PMC article.
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Synergistic effects of treating the spinal cord and brain in CLN1 disease.
Shyng C, Nelvagal HR, Dearborn JT, Tyynelä J, Schmidt RE, Sands MS, Cooper JD.
Shyng C, et al.
Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5920-E5929. doi: 10.1073/pnas.1701832114. Epub 2017 Jul 3.
Proc Natl Acad Sci U S A. 2017.
PMID: 28673981
Free PMC article.
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SMRT Sequencing Enables High-Throughput Identification of Novel AAVs from Capsid Shuffling and Directed Evolution.
Casy W, Garza IT, Chen X, Dong T, Hu Y, Kanchwala M, Trygg CB, Shyng C, Xing C, Bunnell BA, Braun SE, Gray SJ.
Casy W, et al. Among authors: shyng c.
Genes (Basel). 2023 Aug 21;14(8):1660. doi: 10.3390/genes14081660.
Genes (Basel). 2023.
PMID: 37628711
Free PMC article.
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