Shorter J - Search Results

1

Sequestration of TDP-43^216-414 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone.

Peinado JR, Chaplot K, Jarvela TS, Barbieri EM, Shorter J, Lindberg I. Peinado JR, et al. Among authors: shorter j. ACS Chem Neurosci. 2022 Jun 1;13(11):1651-1665. doi: 10.1021/acschemneuro.2c00156. Epub 2022 May 12. ACS Chem Neurosci. 2022. PMID: 35549000 Free PMC article.

2

TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity.

Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, Gitler AD. Johnson BS, et al. Among authors: shorter j. J Biol Chem. 2009 Jul 24;284(30):20329-39. doi: 10.1074/jbc.M109.010264. Epub 2009 May 22. J Biol Chem. 2009. PMID: 19465477 Free PMC article.

3

Disparate Mutations Confer Therapeutic Gain of Hsp104 Function.

Jackrel ME, Yee K, Tariq A, Chen AI, Shorter J. Jackrel ME, et al. Among authors: shorter j. ACS Chem Biol. 2015 Dec 18;10(12):2672-9. doi: 10.1021/acschembio.5b00765. Epub 2015 Oct 15. ACS Chem Biol. 2015. PMID: 26441009 Free PMC article.

4

Chaperones in Neurodegeneration.

Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ. Lindberg I, et al. Among authors: shorter j. J Neurosci. 2015 Oct 14;35(41):13853-9. doi: 10.1523/JNEUROSCI.2600-15.2015. J Neurosci. 2015. PMID: 26468185 Free PMC article. Review.

5

Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies.

Guo L, Shorter J. Guo L, et al. Among authors: shorter j. Cold Spring Harb Perspect Med. 2017 Sep 1;7(9):a024554. doi: 10.1101/cshperspect.a024554. Cold Spring Harb Perspect Med. 2017. PMID: 27920024 Free PMC article. Review.

6

Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization.

McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM. McGurk L, et al. Among authors: shorter j. Mol Cell. 2018 Sep 6;71(5):703-717.e9. doi: 10.1016/j.molcel.2018.07.002. Epub 2018 Aug 9. Mol Cell. 2018. PMID: 30100264 Free PMC article.

7

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle.

Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R. Vogler TO, et al. Among authors: shorter j. Nature. 2018 Nov;563(7732):508-513. doi: 10.1038/s41586-018-0665-2. Epub 2018 Oct 31. Nature. 2018. PMID: 30464263 Free PMC article.

8

Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation.

McGurk L, Gomes E, Guo L, Shorter J, Bonini NM. McGurk L, et al. Among authors: shorter j. Biochemistry. 2018 Dec 26;57(51):6923-6926. doi: 10.1021/acs.biochem.8b00910. Epub 2018 Dec 17. Biochemistry. 2018. PMID: 30540446 Free PMC article.

9

TDP-43 shapeshifts to encipher FTD severity.

Barbieri EM, Shorter J. Barbieri EM, et al. Among authors: shorter j. Nat Neurosci. 2019 Jan;22(1):3-5. doi: 10.1038/s41593-018-0299-6. Nat Neurosci. 2019. PMID: 30559481 No abstract available.

10

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43.

Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, Brodsky JL, Thathiah A, Shorter J, Donnelly CJ. Mann JR, et al. Among authors: shorter j. Neuron. 2019 Apr 17;102(2):321-338.e8. doi: 10.1016/j.neuron.2019.01.048. Epub 2019 Feb 27. Neuron. 2019. PMID: 30826182 Free PMC article.

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