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The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR.
Steffen J, Ngo J, Wang SP, Williams K, Kramer HF, Ho G, Rodriguez C, Yekkala K, Amuzie C, Bialecki R, Norquay L, Nawrocki AR, Erion M, Pocai A, Shirihai OS, Liesa M. Steffen J, et al. Among authors: shirihai os. Mol Metab. 2022 Oct;64:101566. doi: 10.1016/j.molmet.2022.101566. Epub 2022 Aug 6. Mol Metab. 2022. PMID: 35940556 Free PMC article.
Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle.
Blättler SM, Verdeguer F, Liesa M, Cunningham JT, Vogel RO, Chim H, Liu H, Romanino K, Shirihai OS, Vazquez F, Rüegg MA, Shi Y, Puigserver P. Blättler SM, et al. Among authors: shirihai os. Mol Cell Biol. 2012 Aug;32(16):3333-46. doi: 10.1128/MCB.00337-12. Epub 2012 Jun 18. Mol Cell Biol. 2012. PMID: 22711985 Free PMC article.
Hormone-induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure.
Wikstrom JD, Mahdaviani K, Liesa M, Sereda SB, Si Y, Las G, Twig G, Petrovic N, Zingaretti C, Graham A, Cinti S, Corkey BE, Cannon B, Nedergaard J, Shirihai OS. Wikstrom JD, et al. Among authors: shirihai os. EMBO J. 2014 Mar 3;33(5):418-36. doi: 10.1002/embj.201385014. Epub 2014 Jan 15. EMBO J. 2014. PMID: 24431221 Free PMC article.
High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II.
Sverdlov AL, Elezaby A, Behring JB, Bachschmid MM, Luptak I, Tu VH, Siwik DA, Miller EJ, Liesa M, Shirihai OS, Pimentel DR, Cohen RA, Colucci WS. Sverdlov AL, et al. Among authors: shirihai os. J Mol Cell Cardiol. 2015 Jan;78:165-73. doi: 10.1016/j.yjmcc.2014.07.018. Epub 2014 Aug 7. J Mol Cell Cardiol. 2015. PMID: 25109264 Free PMC article.
Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload.
Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ. Elezaby A, et al. Among authors: shirihai os. J Mol Cell Cardiol. 2015 Feb;79:275-83. doi: 10.1016/j.yjmcc.2014.12.001. Epub 2014 Dec 9. J Mol Cell Cardiol. 2015. PMID: 25497302 Free PMC article.
177 results