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Angiogenesis in the ischemic core: A potential treatment target?
Kanazawa M, Takahashi T, Ishikawa M, Onodera O, Shimohata T, Del Zoppo GJ. Kanazawa M, et al. Among authors: shimohata t. J Cereb Blood Flow Metab. 2019 May;39(5):753-769. doi: 10.1177/0271678X19834158. Epub 2019 Mar 6. J Cereb Blood Flow Metab. 2019. PMID: 30841779 Free PMC article. Review.
Transgenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG repeats comparable with those in DRPLA patients.
Sato T, Oyake M, Nakamura K, Nakao K, Fukusima Y, Onodera O, Igarashi S, Takano H, Kikugawa K, Ishida Y, Shimohata T, Koide R, Ikeuchi T, Tanaka H, Futamura N, Matsumura R, Takayanagi T, Tanaka F, Sobue G, Komure O, Takahashi M, Sano A, Ichikawa Y, Goto J, Kanazawa I, et al. Sato T, et al. Among authors: shimohata t. Hum Mol Genet. 1999 Jan;8(1):99-106. doi: 10.1093/hmg/8.1.99. Hum Mol Genet. 1999. PMID: 9887337
Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription.
Shimohata T, Nakajima T, Yamada M, Uchida C, Onodera O, Naruse S, Kimura T, Koide R, Nozaki K, Sano Y, Ishiguro H, Sakoe K, Ooshima T, Sato A, Ikeuchi T, Oyake M, Sato T, Aoyagi Y, Hozumi I, Nagatsu T, Takiyama Y, Nishizawa M, Goto J, Kanazawa I, Davidson I, Tanese N, Takahashi H, Tsuji S. Shimohata T, et al. Nat Genet. 2000 Sep;26(1):29-36. doi: 10.1038/79139. Nat Genet. 2000. PMID: 10973244
Expanded polyglutamine stretches form an 'aggresome'.
Shimohata T, Sato A, Burke JR, Strittmatter WJ, Tsuji S, Onodera O. Shimohata T, et al. Neurosci Lett. 2002 May 3;323(3):215-8. doi: 10.1016/s0304-3940(02)00162-3. Neurosci Lett. 2002. PMID: 11959423
Adult-onset leukoencephalopathy with vanishing white matter with a missense mutation in EIF2B5.
Ohtake H, Shimohata T, Terajima K, Kimura T, Jo R, Kaseda R, Iizuka O, Takano M, Akaiwa Y, Goto H, Kobayashi H, Sugai T, Muratake T, Hosoki T, Shioiri T, Okamoto K, Onodera O, Tanaka K, Someya T, Nakada T, Tsuji S. Ohtake H, et al. Among authors: shimohata t. Neurology. 2004 May 11;62(9):1601-3. doi: 10.1212/01.wnl.0000123117.11264.0e. Neurology. 2004. PMID: 15136690
[Gene diagnosis of patients with chorea].
Shimohata T, Onodera O, Honma Y, Hirota K, Nunomura Y, Kimura T, Kawachi I, Sanpei K, Nishizawa M, Tsuji S. Shimohata T, et al. Rinsho Shinkeigaku. 2004 Mar;44(3):149-53. Rinsho Shinkeigaku. 2004. PMID: 15233265 Japanese.
287 results