Shimada T - Search Results

1

4-Pyridone-3-carboxylic acid as a benzoic acid bioisostere: Design, synthesis, and evaluation of EP300/CBP histone acetyltransferase inhibitors.

Kanada R, Suzuki T, Murata T, Miyazaki M, Shimada T, Kuroha M, Minami M, Higuchi S, Tominaga Y, Naito H. Kanada R, et al. Among authors: shimada t. Bioorg Med Chem Lett. 2021 Nov 1;51:128358. doi: 10.1016/j.bmcl.2021.128358. Epub 2021 Sep 15. Bioorg Med Chem Lett. 2021. PMID: 34534674

2

Design, synthesis, and biological activity of novel factor Xa inhibitors: improving metabolic stability by S1 and S4 ligand modification.

Komoriya S, Kobayashi S, Osanai K, Yoshino T, Nagata T, Haginoya N, Nakamoto Y, Mochizuki A, Nagahara T, Suzuki M, Shimada T, Watanabe K, Isobe Y, Furugoori T. Komoriya S, et al. Among authors: shimada t. Bioorg Med Chem. 2006 Mar 1;14(5):1309-30. doi: 10.1016/j.bmc.2005.09.056. Epub 2005 Nov 2. Bioorg Med Chem. 2006. PMID: 16263291

3

Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold.

Kawai J, Ota M, Ohki H, Toki T, Suzuki M, Shimada T, Matsui S, Inoue H, Sugihara C, Matsuhashi N, Matsui Y, Takaishi S, Nakayama K. Kawai J, et al. Among authors: shimada t. ACS Med Chem Lett. 2019 May 24;10(6):893-898. doi: 10.1021/acsmedchemlett.9b00069. eCollection 2019 Jun 13. ACS Med Chem Lett. 2019. PMID: 31223444 Free PMC article.

4

Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity.

Kawai J, Toki T, Ota M, Inoue H, Takata Y, Asahi T, Suzuki M, Shimada T, Ono K, Suzuki K, Takaishi S, Ohki H, Matsui S, Tsutsumi S, Hirota Y, Nakayama K. Kawai J, et al. Among authors: shimada t. J Med Chem. 2019 Nov 27;62(22):10204-10220. doi: 10.1021/acs.jmedchem.9b01113. Epub 2019 Nov 18. J Med Chem. 2019. PMID: 31638799

5

Synthesis and conformational analysis of a non-amidine factor Xa inhibitor that incorporates 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 binding element.

Haginoya N, Kobayashi S, Komoriya S, Yoshino T, Suzuki M, Shimada T, Watanabe K, Hirokawa Y, Furugori T, Nagahara T. Haginoya N, et al. Among authors: shimada t. J Med Chem. 2004 Oct 7;47(21):5167-82. doi: 10.1021/jm049884d. J Med Chem. 2004. PMID: 15456260

6

Structure of N-myristoyltransferase from Aspergillus fumigatus.

Shimada T, Suzuki M, Katakura S. Shimada T, et al. Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):754-61. doi: 10.1107/S1399004715000401. Epub 2015 Mar 26. Acta Crystallogr D Biol Crystallogr. 2015. PMID: 25849386

7

Revisiting biomolecular NMR spectroscopy for promoting small-molecule drug discovery.

Hanzawa H, Shimada T, Takahashi M, Takahashi H. Hanzawa H, et al. Among authors: shimada t. J Biomol NMR. 2020 Nov;74(10-11):501-508. doi: 10.1007/s10858-020-00314-0. Epub 2020 Apr 18. J Biomol NMR. 2020. PMID: 32306215 Review.

8

Discovery of a Novel ATP-Competitive MEK Inhibitor DS03090629 that Overcomes Resistance Conferred by BRAF Overexpression in BRAF-Mutated Melanoma.

Takano K, Munehira Y, Hatanaka M, Murakami R, Shibata Y, Shida T, Takeuchi K, Takechi S, Tabata T, Shimada T, Kishikawa S, Matsui Y, Ubukata O, Seki T, Kaneta Y. Takano K, et al. Among authors: shimada t. Mol Cancer Ther. 2023 Mar 2;22(3):317-332. doi: 10.1158/1535-7163.MCT-22-0306. Mol Cancer Ther. 2023. PMID: 36622773

9

Determination of key residues in MRGPRX2 to enhance pseudo-allergic reactions induced by fluoroquinolones.

Hamamura-Yasuno E, Matsushita J, Sato S, Shimada T, Tsuchiya Y, Fujimoto K, Mori K. Hamamura-Yasuno E, et al. Among authors: shimada t. Sci Rep. 2022 Apr 22;12(1):6650. doi: 10.1038/s41598-022-10549-6. Sci Rep. 2022. PMID: 35459883 Free PMC article.

10

[The role of pharmacology to produce firuglipel (DS-8500a), an orally available GPR119 agonist for type 2 diabetes mellitus].

Matsumoto K, Yoshitomi T, Shimada T. Matsumoto K, et al. Among authors: shimada t. Nihon Yakurigaku Zasshi. 2018;152(3):119-124. doi: 10.1254/fpj.152.119. Nihon Yakurigaku Zasshi. 2018. PMID: 30185729 Japanese.

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