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A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model.
Machida Y, Nakagawa M, Matsunaga H, Yamaguchi M, Ogawara Y, Shima Y, Yamagata K, Katsumoto T, Hattori A, Itoh M, Seki T, Nishiya Y, Nakamura K, Suzuki K, Imaoka T, Baba D, Suzuki M, Sampetrean O, Saya H, Ichimura K, Kitabayashi I. Machida Y, et al. Among authors: shima y. Mol Cancer Ther. 2020 Feb;19(2):375-383. doi: 10.1158/1535-7163.MCT-18-1349. Epub 2019 Nov 14. Mol Cancer Ther. 2020. PMID: 31727689
Deregulated transcription factors in leukemia.
Shima Y, Kitabayashi I. Shima Y, et al. Int J Hematol. 2011 Aug;94(2):134-141. doi: 10.1007/s12185-011-0905-9. Epub 2011 Aug 9. Int J Hematol. 2011. PMID: 21823042 Review.
MLL is essential for NUP98-HOXA9-induced leukemia.
Shima Y, Yumoto M, Katsumoto T, Kitabayashi I. Shima Y, et al. Leukemia. 2017 Oct;31(10):2200-2210. doi: 10.1038/leu.2017.62. Epub 2017 Feb 17. Leukemia. 2017. PMID: 28210005
CDKN1C-mediated growth inhibition by an EZH1/2 dual inhibitor overcomes resistance of mantle cell lymphoma to ibrutinib.
Kagiyama Y, Fujita S, Shima Y, Yamagata K, Katsumoto T, Nakagawa M, Honma D, Adachi N, Araki K, Kato A, Inaki K, Ono Y, Fukuhara S, Kobayashi Y, Tobinai K, Kitabayashi I. Kagiyama Y, et al. Among authors: shima y. Cancer Sci. 2021 Jun;112(6):2314-2324. doi: 10.1111/cas.14905. Epub 2021 May 1. Cancer Sci. 2021. PMID: 33792119 Free PMC article.
795 results