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Development of Highly Potent Noncovalent Inhibitors of SARS-CoV-2 3CLpro.
Hou N, Shuai L, Zhang L, Xie X, Tang K, Zhu Y, Yu Y, Zhang W, Tan Q, Zhong G, Wen Z, Wang C, He X, Huo H, Gao H, Xu Y, Xue J, Peng C, Zou J, Schindewolf C, Menachery V, Su W, Yuan Y, Shen Z, Zhang R, Yuan S, Yu H, Shi PY, Bu Z, Huang J, Hu Q. Hou N, et al. Among authors: shi py. ACS Cent Sci. 2023 Jan 25;9(2):217-227. doi: 10.1021/acscentsci.2c01359. eCollection 2023 Feb 22. ACS Cent Sci. 2023. PMID: 36844503 Free PMC article.
The N501Y spike substitution enhances SARS-CoV-2 transmission.
Liu Y, Liu J, Plante KS, Plante JA, Xie X, Zhang X, Ku Z, An Z, Scharton D, Schindewolf C, Menachery VD, Shi PY, Weaver SC. Liu Y, et al. Among authors: shi py. bioRxiv [Preprint]. 2021 Mar 9:2021.03.08.434499. doi: 10.1101/2021.03.08.434499. bioRxiv. 2021. PMID: 33758836 Free PMC article. Updated. Preprint.
Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
Muruato A, Vu MN, Johnson BA, Davis-Gardner ME, Vanderheiden A, Lokugmage K, Schindewolf C, Crocquet-Valdes PA, Langsjoen RM, Plante JA, Plante KS, Weaver SC, Debbink K, Routh AL, Walker D, Suthar MS, Xie X, Shi PY, Xie X, Menachery VD. Muruato A, et al. Among authors: shi py. bioRxiv [Preprint]. 2021 May 4:2021.05.03.442357. doi: 10.1101/2021.05.03.442357. bioRxiv. 2021. PMID: 33972939 Free PMC article. Updated. Preprint.
Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.
Liu Y, Liu J, Johnson BA, Xia H, Ku Z, Schindewolf C, Widen SG, An Z, Weaver SC, Menachery VD, Xie X, Shi PY. Liu Y, et al. Among authors: shi py. bioRxiv [Preprint]. 2021 Sep 5:2021.08.12.456173. doi: 10.1101/2021.08.12.456173. bioRxiv. 2021. PMID: 34462752 Free PMC article. Updated. Preprint.
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
Johnson BA, Zhou Y, Lokugamage KG, Vu MN, Bopp N, Crocquet-Valdes PA, Kalveram B, Schindewolf C, Liu Y, Scharton D, Plante JA, Xie X, Aguilar P, Weaver SC, Shi PY, Walker DH, Routh AL, Plante KS, Menachery VD. Johnson BA, et al. Among authors: shi py. bioRxiv [Preprint]. 2022 Mar 28:2021.10.14.464390. doi: 10.1101/2021.10.14.464390. bioRxiv. 2022. PMID: 34671771 Free PMC article. Updated. Preprint.
A modified porous silicon microparticle promotes mucosal delivery of SARS-CoV-2 antigen and induction of potent and durable systemic and mucosal T helper 1 skewed protective immunity.
Adam A, Shi Q, Wang B, Zou J, Mai J, Osman SR, Wu W, Xie X, Aguilar PV, Bao X, Shi PY, Shen H, Wang T. Adam A, et al. Among authors: shi q, shi py. bioRxiv [Preprint]. 2021 Nov 24:2021.11.22.469576. doi: 10.1101/2021.11.22.469576. bioRxiv. 2021. PMID: 34845456 Free PMC article. Preprint.
Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Ku Z, Xie X, Lin J, Gao P, El Sahili A, Su H, Liu Y, Ye X, Li X, Fan X, Goh BC, Xiong W, Boyd H, Muruato AE, Deng H, Xia H, Jing Z, Kalveram BK, Menachery VD, Zhang N, Lescar J, Shi PY, An Z. Ku Z, et al. Among authors: shi py. bioRxiv [Preprint]. 2022 Feb 1:2022.02.01.478504. doi: 10.1101/2022.02.01.478504. bioRxiv. 2022. PMID: 35132410 Free PMC article. Updated. Preprint.
A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions.
Liu Y, Zhang X, Liu J, Xia H, Zou J, Muruato AE, Periasamy S, Plante JA, Bopp NE, Kurhade C, Bukreyev A, Ren P, Wang T, Menachery VD, Plante KS, Xie X, Weaver SC, Shi PY. Liu Y, et al. Among authors: shi py. bioRxiv [Preprint]. 2022 Feb 15:2022.02.14.480460. doi: 10.1101/2022.02.14.480460. bioRxiv. 2022. PMID: 35194609 Free PMC article. Updated. Preprint.
473 results