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APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints.
Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, Cheng Y, Barry JL, Krishnan RK, Wakelin S, Rhee J, Yung A, Aronchik M, Wang C, Jain N, Bao X, Gerrits E, Brouwer N, Deik A, Tenen DG, Ikezu T, Santander NG, McKinsey GL, Baufeld C, Sheppard D, Krasemann S, Nowarski R, Eggen BJL, Clish C, Tanzi RE, Madore C, Arnold TD, Holtzman DM, Butovsky O. Yin Z, et al. Among authors: sheppard d. Nat Immunol. 2023 Nov;24(11):1839-1853. doi: 10.1038/s41590-023-01627-6. Epub 2023 Sep 25. Nat Immunol. 2023. PMID: 37749326
Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Henderson NC, et al. Among authors: sheppard d. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10. Nat Med. 2013. PMID: 24216753 Free PMC article.
The αvβ1 integrin plays a critical in vivo role in tissue fibrosis.
Reed NI, Jo H, Chen C, Tsujino K, Arnold TD, DeGrado WF, Sheppard D. Reed NI, et al. Among authors: sheppard d. Sci Transl Med. 2015 May 20;7(288):288ra79. doi: 10.1126/scitranslmed.aaa5094. Sci Transl Med. 2015. PMID: 25995225 Free PMC article.
αVβ8 integrin targeting to prevent posterior capsular opacification.
Shihan MH, Novo SG, Wang Y, Sheppard D, Atakilit A, Arnold TD, Rossi NM, Faranda AP, Duncan MK. Shihan MH, et al. Among authors: sheppard d. JCI Insight. 2021 Nov 8;6(21):e145715. doi: 10.1172/jci.insight.145715. JCI Insight. 2021. PMID: 34554928 Free PMC article.
Stromal cells control the epithelial residence of DCs and memory T cells by regulated activation of TGF-β.
Mohammed J, Beura LK, Bobr A, Astry B, Chicoine B, Kashem SW, Welty NE, Igyártó BZ, Wijeyesinghe S, Thompson EA, Matte C, Bartholin L, Kaplan A, Sheppard D, Bridges AG, Shlomchik WD, Masopust D, Kaplan DH. Mohammed J, et al. Among authors: sheppard d. Nat Immunol. 2016 Apr;17(4):414-21. doi: 10.1038/ni.3396. Epub 2016 Feb 22. Nat Immunol. 2016. PMID: 26901152 Free PMC article.
896 results