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Recombinant RquA catalyzes the in vivo conversion of ubiquinone to rhodoquinone in Escherichia coli and Saccharomyces cerevisiae.
Bernert AC, Jacobs EJ, Reinl SR, Choi CCY, Roberts Buceta PM, Culver JC, Goodspeed CR, Bradley MC, Clarke CF, Basset GJ, Shepherd JN. Bernert AC, et al. Among authors: shepherd jn. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Sep;1864(9):1226-1234. doi: 10.1016/j.bbalip.2019.05.007. Epub 2019 May 21. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31121262 Free PMC article.
The kynurenine pathway is essential for rhodoquinone biosynthesis in Caenorhabditis elegans.
Roberts Buceta PM, Romanelli-Cedrez L, Babcock SJ, Xun H, VonPaige ML, Higley TW, Schlatter TD, Davis DC, Drexelius JA, Culver JC, Carrera I, Shepherd JN, Salinas G. Roberts Buceta PM, et al. Among authors: shepherd jn. J Biol Chem. 2019 Jul 12;294(28):11047-11053. doi: 10.1074/jbc.AC119.009475. Epub 2019 Jun 7. J Biol Chem. 2019. PMID: 31177094 Free PMC article.
Microbial rhodoquinone biosynthesis proceeds via an atypical RquA-catalyzed amino transfer from S-adenosyl-L-methionine to ubiquinone.
Neupane T, Chambers LR, Godfrey AJ, Monlux MM, Jacobs EJ, Whitworth S, Spawn JE, Clingman SHK, Vergunst KL, Niven FM, Townley JJ, Orion IW, Goodspeed CR, Cooper KA, Cronk JD, Shepherd JN, Langelaan DN. Neupane T, et al. Among authors: shepherd jn. Commun Chem. 2022 Aug 1;5(1):89. doi: 10.1038/s42004-022-00711-6. Commun Chem. 2022. PMID: 36697674 Free PMC article.
23 results