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Parallel Accumulation of Tumor Hyaluronan, Collagen, and Other Drivers of Tumor Progression.
Li X, Shepard HM, Cowell JA, Zhao C, Osgood RJ, Rosengren S, Blouw B, Garrovillo SA, Pagel MD, Whatcott CJ, Han H, Von Hoff DD, Taverna DM, LaBarre MJ, Maneval DC, Thompson CB. Li X, et al. Among authors: shepard hm. Clin Cancer Res. 2018 Oct 1;24(19):4798-4807. doi: 10.1158/1078-0432.CCR-17-3284. Epub 2018 Jul 3. Clin Cancer Res. 2018. PMID: 30084839 Free PMC article.
Therapeutic targeting of hyaluronan in the tumor stroma.
Kultti A, Li X, Jiang P, Thompson CB, Frost GI, Shepard HM. Kultti A, et al. Among authors: shepard hm. Cancers (Basel). 2012 Sep 6;4(3):873-903. doi: 10.3390/cancers4030873. Cancers (Basel). 2012. PMID: 24213471 Free PMC article.
Accumulation of extracellular hyaluronan by hyaluronan synthase 3 promotes tumor growth and modulates the pancreatic cancer microenvironment.
Kultti A, Zhao C, Singha NC, Zimmerman S, Osgood RJ, Symons R, Jiang P, Li X, Thompson CB, Infante JR, Jacobetz MA, Tuveson DA, Frost GI, Shepard HM, Huang Z. Kultti A, et al. Among authors: shepard hm. Biomed Res Int. 2014;2014:817613. doi: 10.1155/2014/817613. Epub 2014 Jul 24. Biomed Res Int. 2014. PMID: 25147816 Free PMC article.
A recombinant human enzyme for enhanced interstitial transport of therapeutics.
Bookbinder LH, Hofer A, Haller MF, Zepeda ML, Keller GA, Lim JE, Edgington TS, Shepard HM, Patton JS, Frost GI. Bookbinder LH, et al. Among authors: shepard hm. J Control Release. 2006 Aug 28;114(2):230-41. doi: 10.1016/j.jconrel.2006.05.027. Epub 2006 Jun 7. J Control Release. 2006. PMID: 16876899
Recombinant human hyaluronidase PH20 does not stimulate an acute inflammatory response and inhibits lipopolysaccharide-induced neutrophil recruitment in the air pouch model of inflammation.
Huang Z, Zhao C, Chen Y, Cowell JA, Wei G, Kultti A, Huang L, Thompson CB, Rosengren S, Frost GI, Shepard HM. Huang Z, et al. Among authors: shepard hm. J Immunol. 2014 Jun 1;192(11):5285-95. doi: 10.4049/jimmunol.1303060. Epub 2014 Apr 28. J Immunol. 2014. PMID: 24778442
95 results