Shen C - Search Results

1

Inhibition of MEK confers hypersensitivity to X-radiation in the context of BRAF mutation in a model of childhood astrocytoma.

Studebaker A, Bondra K, Seum S, Shen C, Phelps DA, Chronowski C, Leasure J, Smith PD, Kurmasheva RT, Mo X, Fouladi M, Houghton PJ. Studebaker A, et al. Among authors: shen c. Pediatr Blood Cancer. 2015 Oct;62(10):1768-74. doi: 10.1002/pbc.25579. Epub 2015 May 15. Pediatr Blood Cancer. 2015. PMID: 25981859 Free PMC article.

2

Regulation of FANCD2 by the mTOR pathway contributes to the resistance of cancer cells to DNA double-strand breaks.

Shen C, Oswald D, Phelps D, Cam H, Pelloski CE, Pang Q, Houghton PJ. Shen C, et al. Cancer Res. 2013 Jun 1;73(11):3393-401. doi: 10.1158/0008-5472.CAN-12-4282. Epub 2013 Apr 30. Cancer Res. 2013. PMID: 23633493 Free PMC article.

3

The mTOR pathway negatively controls ATM by up-regulating miRNAs.

Shen C, Houghton PJ. Shen C, et al. Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11869-74. doi: 10.1073/pnas.1220898110. Epub 2013 Jul 1. Proc Natl Acad Sci U S A. 2013. PMID: 23818585 Free PMC article.

4

FANCD2 is a potential therapeutic target and biomarker in alveolar rhabdomyosarcoma harboring the PAX3-FOXO1 fusion gene.

Singh M, Leasure JM, Chronowski C, Geier B, Bondra K, Duan W, Hensley LA, Villalona-Calero M, Li N, Vergis AM, Kurmasheva RT, Shen C, Woods G, Sebastian N, Fabian D, Kaplon R, Hammond S, Palanichamy K, Chakravarti A, Houghton PJ. Singh M, et al. Among authors: shen c. Clin Cancer Res. 2014 Jul 15;20(14):3884-95. doi: 10.1158/1078-0432.CCR-13-0556. Epub 2014 Apr 30. Clin Cancer Res. 2014. PMID: 24787670 Free PMC article.

5

Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells.

Zhou X, Liu W, Hu X, Dorrance A, Garzon R, Houghton PJ, Shen C. Zhou X, et al. Among authors: shen c. Sci Rep. 2017 May 8;7(1):1535. doi: 10.1038/s41598-017-01729-w. Sci Rep. 2017. PMID: 28484242 Free PMC article.

6

P53 suppresses ribonucleotide reductase via inhibiting mTORC1.

He Z, Hu X, Liu W, Dorrance A, Garzon R, Houghton PJ, Shen C. He Z, et al. Among authors: shen c. Oncotarget. 2017 Jun 20;8(25):41422-41431. doi: 10.18632/oncotarget.17440. Oncotarget. 2017. PMID: 28507282 Free PMC article.

7

Targeting FANCD2 for therapy sensitization.

Shen C, Houghton PJ. Shen C, et al. Oncotarget. 2014 Jun 15;5(11):3426-7. doi: 10.18632/oncotarget.2070. Oncotarget. 2014. PMID: 24913333 Free PMC article. No abstract available.

8

Regulation of DNA duplication by the mTOR signaling pathway.

He Z, Houghton PJ, Williams TM, Shen C. He Z, et al. Among authors: shen c. Cell Cycle. 2021 Apr;20(8):742-751. doi: 10.1080/15384101.2021.1897271. Epub 2021 Mar 10. Cell Cycle. 2021. PMID: 33691584 Free PMC article. Review.

9

mTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase.

Wu X, Li S, Hu X, Xiang X, Halloran M, Yang L, Williams TM, Houghton PJ, Shen C, He Z. Wu X, et al. Among authors: shen c. Sci Rep. 2019 Jul 8;9(1):9805. doi: 10.1038/s41598-019-46052-8. Sci Rep. 2019. PMID: 31285446 Free PMC article.

10

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair.

Yang L, Shen C, Estrada-Bernal A, Robb R, Chatterjee M, Sebastian N, Webb A, Mo X, Chen W, Krishnan S, Williams TM. Yang L, et al. Among authors: shen c. Nucleic Acids Res. 2021 Nov 8;49(19):11067-11082. doi: 10.1093/nar/gkab871. Nucleic Acids Res. 2021. PMID: 34606602 Free PMC article.

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