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Page 1
Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes.
Gunasekar SK, Xie L, Kumar A, Hong J, Chheda PR, Kang C, Kern DM, My-Ta C, Maurer J, Heebink J, Gerber EE, Grzesik WJ, Elliot-Hudson M, Zhang Y, Key P, Kulkarni CA, Beals JW, Smith GI, Samuel I, Smith JK, Nau P, Imai Y, Sheldon RD, Taylor EB, Lerner DJ, Norris AW, Klein S, Brohawn SG, Kerns R, Sah R. Gunasekar SK, et al. Among authors: sheldon rd. Nat Commun. 2022 Feb 10;13(1):784. doi: 10.1038/s41467-022-28435-0. Nat Commun. 2022. PMID: 35145074 Free PMC article.
Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness.
Sharma A, Oonthonpan L, Sheldon RD, Rauckhorst AJ, Zhu Z, Tompkins SC, Cho K, Grzesik WJ, Gray LR, Scerbo DA, Pewa AD, Cushing EM, Dyle MC, Cox JE, Adams C, Davies BS, Shields RK, Norris AW, Patti G, Zingman LV, Taylor EB. Sharma A, et al. Among authors: sheldon rd. Elife. 2019 Jul 18;8:e45873. doi: 10.7554/eLife.45873. Elife. 2019. PMID: 31305240 Free PMC article.
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.
Tompkins SC, Sheldon RD, Rauckhorst AJ, Noterman MF, Solst SR, Buchanan JL, Mapuskar KA, Pewa AD, Gray LR, Oonthonpan L, Sharma A, Scerbo DA, Dupuy AJ, Spitz DR, Taylor EB. Tompkins SC, et al. Among authors: sheldon rd. Cell Rep. 2019 Sep 3;28(10):2608-2619.e6. doi: 10.1016/j.celrep.2019.07.098. Cell Rep. 2019. PMID: 31484072 Free PMC article.
Critical Role for Hepatocyte-Specific eNOS in NAFLD and NASH.
Cunningham RP, Moore MP, Dashek RJ, Meers GM, Takahashi T, Sheldon RD, Wheeler AA, Diaz-Arias A, Ibdah JA, Parks EJ, Thyfault JP, Rector RS. Cunningham RP, et al. Among authors: sheldon rd. Diabetes. 2021 Nov;70(11):2476-2491. doi: 10.2337/db20-1228. Epub 2021 Aug 11. Diabetes. 2021. PMID: 34380696 Free PMC article.
Chronic NOS inhibition accelerates NAFLD progression in an obese rat model.
Sheldon RD, Padilla J, Jenkins NT, Laughlin MH, Rector RS. Sheldon RD, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 15;308(6):G540-9. doi: 10.1152/ajpgi.00247.2014. Epub 2015 Jan 8. Am J Physiol Gastrointest Liver Physiol. 2015. PMID: 25573175 Free PMC article.
45 results