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Vitamin B12 and folate decrease inflammation and fibrosis in NASH by preventing syntaxin 17 homocysteinylation.
Tripathi M, Singh BK, Zhou J, Tikno K, Widjaja A, Sandireddy R, Arul K, Abdul Ghani SAB, Bee GGB, Wong KA, Pei HJ, Shekeran SG, Sinha RA, Singh MK, Cook SA, Suzuki A, Lim TR, Cheah CC, Wang J, Xiao RP, Zhang X, Chow PKH, Yen PM. Tripathi M, et al. Among authors: shekeran sg. J Hepatol. 2022 Nov;77(5):1246-1255. doi: 10.1016/j.jhep.2022.06.033. Epub 2022 Jul 9. J Hepatol. 2022. PMID: 35820507 Free article.
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.
Widjaja AA, Singh BK, Adami E, Viswanathan S, Dong J, D'Agostino GA, Ng B, Lim WW, Tan J, Paleja BS, Tripathi M, Lim SY, Shekeran SG, Chothani SP, Rabes A, Sombetzki M, Bruinstroop E, Min LP, Sinha RA, Albani S, Yen PM, Schafer S, Cook SA. Widjaja AA, et al. Among authors: shekeran sg. Gastroenterology. 2019 Sep;157(3):777-792.e14. doi: 10.1053/j.gastro.2019.05.002. Epub 2019 May 9. Gastroenterology. 2019. PMID: 31078624 Free article.
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
Widjaja AA, Dong J, Adami E, Viswanathan S, Ng B, Pakkiri LS, Chothani SP, Singh BK, Lim WW, Zhou J, Shekeran SG, Tan J, Lim SY, Goh J, Wang M, Holgate R, Hearn A, Felkin LE, Yen PM, Dear JW, Drum CL, Schafer S, Cook SA. Widjaja AA, et al. Among authors: shekeran sg. Sci Transl Med. 2021 Jun 9;13(597):eaba8146. doi: 10.1126/scitranslmed.aba8146. Sci Transl Med. 2021. PMID: 34108253
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury.
Dong J, Lim WW, Shekeran SG, Tan J, Lim SY, Goh JWT, George BL, Schafer S, Cook SA, Widjaja AA. Dong J, et al. Among authors: shekeran sg. Int J Mol Sci. 2022 Jun 25;23(13):7089. doi: 10.3390/ijms23137089. Int J Mol Sci. 2022. PMID: 35806094 Free PMC article.
14 results