Shapiro TA - Search Results

1

Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice.

Moon DK, Singhal V, Kumar N, Shapiro TA, Posner GH. Moon DK, et al. Among authors: shapiro ta. Drug Dev Res. 2009 Jan 1;71(1):76-81. doi: 10.1002/ddr.20350. Drug Dev Res. 2009. PMID: 20686674 Free PMC article.

2

Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.

Posner GH, Wang D, Cumming JN, Oh CH, French AN, Bodley AL, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1995 Jun 23;38(13):2273-5. doi: 10.1021/jm00013a001. J Med Chem. 1995. PMID: 7608890 No abstract available.

3

Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.

Posner GH, Ploypradith P, Hapangama W, Wang D, Cumming JN, Dolan P, Kensler TW, Klinedinst D, Shapiro TA, Zheng QY, Murray CK, Pilkington LG, Jayasinghe LR, Bray JF, Daughenbaugh R. Posner GH, et al. Among authors: shapiro ta. Bioorg Med Chem. 1997 Jul;5(7):1257-65. doi: 10.1016/s0968-0896(97)00079-5. Bioorg Med Chem. 1997. PMID: 9377085 Free article.

4

Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.

Posner GH, Cumming JN, Woo SH, Ploypradith P, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1998 Mar 12;41(6):940-51. doi: 10.1021/jm970686e. J Med Chem. 1998. PMID: 9526568

5

Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin.

Cumming JN, Wang D, Park SB, Shapiro TA, Posner GH. Cumming JN, et al. Among authors: shapiro ta. J Med Chem. 1998 Mar 12;41(6):952-64. doi: 10.1021/jm970711g. J Med Chem. 1998. PMID: 9526569

6

Antimalarial cyclic peroxy ketals.

Posner GH, O'Dowd H, Ploypradith P, Cumming JN, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1998 Jun 4;41(12):2164-7. doi: 10.1021/jm980088f. J Med Chem. 1998. PMID: 9622557

7

Synthesis and in vitro antimalarial activity of sulfone endoperoxides.

Bachi MD, Korshin EE, Ploypradith P, Cumming JN, Xie S, Shapiro TA, Posner GH. Bachi MD, et al. Among authors: shapiro ta. Bioorg Med Chem Lett. 1998 Apr 21;8(8):903-8. doi: 10.1016/s0960-894x(98)00141-3. Bioorg Med Chem Lett. 1998. PMID: 9871509 Free article.

8

Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.

Posner GH, Parker MH, Northrop J, Elias JS, Ploypradith P, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1999 Jan 28;42(2):300-4. doi: 10.1021/jm980529v. J Med Chem. 1999. PMID: 9925735

9

Prophylactic activity of atovaquone against Plasmodium falciparum in humans.

Shapiro TA, Ranasinha CD, Kumar N, Barditch-Crovo P. Shapiro TA, et al. Am J Trop Med Hyg. 1999 May;60(5):831-6. doi: 10.4269/ajtmh.1999.60.831. Am J Trop Med Hyg. 1999. PMID: 10344660 Clinical Trial.

10

Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.

Posner GH, Ploypradith P, Parker MH, O'Dowd H, Woo SH, Northrop J, Krasavin M, Dolan P, Kensler TW, Xie S, Shapiro TA. Posner GH, et al. Among authors: shapiro ta. J Med Chem. 1999 Oct 21;42(21):4275-80. doi: 10.1021/jm990363d. J Med Chem. 1999. PMID: 10543871

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