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Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models.
Kaiser FK, Hernandez MG, Krüger N, Englund E, Du W, Mykytyn AZ, Raadsen MP, Lamers MM, Rodrigues Ianiski F, Shamorkina TM, Snijder J, Armando F, Beythien G, Ciurkiewicz M, Schreiner T, Gruber-Dujardin E, Bleyer M, Batura O, Erffmeier L, Hinkel R, Rocha C, Mirolo M, Drabek D, Bosch BJ, Emalfarb M, Valbuena N, Tchelet R, Baumgärtner W, Saloheimo M, Pöhlmann S, Grosveld F, Haagmans BL, Osterhaus ADME. Kaiser FK, et al. Among authors: shamorkina tm. Nat Commun. 2024 Mar 14;15(1):2319. doi: 10.1038/s41467-024-46443-0. Nat Commun. 2024. PMID: 38485931 Free PMC article.
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Hurdiss DL, El Kazzi P, Bauer L, Papageorgiou N, Ferron FP, Donselaar T, van Vliet ALW, Shamorkina TM, Snijder J, Canard B, Decroly E, Brancale A, Zeev-Ben-Mordehai T, Förster F, van Kuppeveld FJM, Coutard B. Hurdiss DL, et al. Among authors: shamorkina tm. Sci Adv. 2022 Jan 7;8(1):eabj7615. doi: 10.1126/sciadv.abj7615. Epub 2022 Jan 5. Sci Adv. 2022. PMID: 34985963 Free PMC article.
Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins.
Bouwman KM, Tomris I, Turner HL, van der Woude R, Shamorkina TM, Bosman GP, Rockx B, Herfst S, Snijder J, Haagmans BL, Ward AB, Boons GJ, de Vries RP. Bouwman KM, et al. Among authors: shamorkina tm. PLoS Pathog. 2021 Feb 8;17(2):e1009282. doi: 10.1371/journal.ppat.1009282. eCollection 2021 Feb. PLoS Pathog. 2021. PMID: 33556147 Free PMC article.
Mass Spectrometry-Based Structural Virology.
Wörner TP, Shamorkina TM, Snijder J, Heck AJR. Wörner TP, et al. Among authors: shamorkina tm. Anal Chem. 2021 Jan 12;93(1):620-640. doi: 10.1021/acs.analchem.0c04339. Epub 2020 Dec 4. Anal Chem. 2021. PMID: 33275424 Free PMC article. Review. No abstract available.
Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family.
Klychnikov OI, Shamorkina TM, Weeks SD, van Leeuwen HC, Corver J, Drijfhout JW, van Veelen PA, Sluchanko NN, Strelkov SV, Hensbergen PJ. Klychnikov OI, et al. Among authors: shamorkina tm. J Biol Chem. 2018 Jul 13;293(28):11154-11165. doi: 10.1074/jbc.RA118.003244. Epub 2018 May 23. J Biol Chem. 2018. PMID: 29794027 Free PMC article.