Shakhnovich V - Search Results

1

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing.

Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL, Scott SA, Schwab M, Uppugunduri CRS, Formea CM, Franciosi JP, Sangkuhl K, Gaedigk A, Klein TE, Gammal RS, Furuta T. Lima JJ, et al. Among authors: shakhnovich v. Clin Pharmacol Ther. 2021 Jun;109(6):1417-1423. doi: 10.1002/cpt.2015. Epub 2020 Sep 20. Clin Pharmacol Ther. 2021. PMID: 32770672 Free PMC article.

2

Failure of proton pump inhibitors to treat GERD in neonates and infants: a question of drug, diagnosis, or design.

Shakhnovich V, Ward RM, Kearns GL. Shakhnovich V, et al. Clin Pharmacol Ther. 2012 Sep;92(3):388-92. doi: 10.1038/clpt.2012.86. Epub 2012 Jul 18. Clin Pharmacol Ther. 2012. PMID: 22805424 Free PMC article. Review.

3

Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity.

Shakhnovich V, Abdel-Rahman S, Friesen CA, Weigel J, Pearce RE, Gaedigk A, Leeder JS, Kearns GL. Shakhnovich V, et al. Pediatr Obes. 2019 Jan;14(1):10.1111/ijpo.12459. doi: 10.1111/ijpo.12459. Epub 2018 Sep 26. Pediatr Obes. 2019. PMID: 30257076 Free PMC article. Clinical Trial.

4

Utility of the ¹³ C-pantoprazole breath test as a CYP2C19 phenotyping probe for children.

Feldman K, Kearns GL, Pearce RE, Abdel-Rahman SM, Steven Leeder J, Friesen A, Staggs VS, Gaedigk A, Weigel J, Shakhnovich V. Feldman K, et al. Among authors: shakhnovich v. Clin Transl Sci. 2022 May;15(5):1155-1166. doi: 10.1111/cts.13232. Epub 2022 Feb 14. Clin Transl Sci. 2022. PMID: 35099109 Free PMC article. Clinical Trial.

5

A fresh look at proton pump inhibitor (PPI)-associated adverse events through a CYP2C19 pharmacogenetic lens.

Chevalier R, Attard T, Van Driest SL, Shakhnovich V. Chevalier R, et al. Among authors: shakhnovich v. Expert Opin Drug Metab Toxicol. 2023 Feb;19(2):53-56. doi: 10.1080/17425255.2023.2190883. Epub 2023 Mar 23. Expert Opin Drug Metab Toxicol. 2023. PMID: 36919492 No abstract available.

6

Influence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children.

Kyler KE, Gaedigk A, Abdel-Rahman S, Staggs VS, Pearce RE, Toren P, Leeder JS, Shakhnovich V. Kyler KE, et al. Among authors: shakhnovich v. Clin Transl Sci. 2024 Apr;17(4):e13782. doi: 10.1111/cts.13782. Clin Transl Sci. 2024. PMID: 38629502 Free PMC article.

7

Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures.

Shakhnovich V, Smith PB, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL; Best Pharmaceuticals for Children Act – Pediatric Trials Network. Shakhnovich V, et al. J Pediatr. 2018 Feb;193:102-108.e1. doi: 10.1016/j.jpeds.2017.10.011. J Pediatr. 2018. PMID: 29389444 Free PMC article. Clinical Trial.

8

A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents.

Shakhnovich V, Brian Smith P, Guptill JT, James LP, Collier DN, Wu H, Livingston CE, Zhao J, Kearns GL, Cohen-Wolkowiez M; Best Pharmaceuticals for Children Act–Pediatric Trials Network. Shakhnovich V, et al. Paediatr Drugs. 2018 Oct;20(5):483-495. doi: 10.1007/s40272-018-0305-1. Paediatr Drugs. 2018. PMID: 30097906 Free PMC article.

9

Effects of obesity on the pharmacology of proton pump inhibitors: current understanding and future implications for patient care and research.

Jafri F, Taylor ZL, Gonzalez D, Shakhnovich V. Jafri F, et al. Among authors: shakhnovich v. Expert Opin Drug Metab Toxicol. 2023 Jan;19(1):1-11. doi: 10.1080/17425255.2023.2178897. Epub 2023 Feb 18. Expert Opin Drug Metab Toxicol. 2023. PMID: 36800927 Free PMC article. Review.

10

Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine.

Vyhlidal CA, Chapron BD, Ahmed A, Singh V, Casini R, Shakhnovich V. Vyhlidal CA, et al. Among authors: shakhnovich v. Clin Transl Sci. 2021 Mar;14(2):729-736. doi: 10.1111/cts.12938. Epub 2020 Dec 16. Clin Transl Sci. 2021. PMID: 33278326 Free PMC article.

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