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Pharmacological inhibition of HPK1 synergizes with PD-L1 blockade to provoke antitumor immunity against tumors with low antigenicity.
Biochem Biophys Res Commun. 2024 Jun 30;715:149995. doi: 10.1016/j.bbrc.2024.149995. Epub 2024 Apr 24.
Biochem Biophys Res Commun. 2024.
PMID: 38685185
Highly potent, orally active novel small-molecule HPK1 inhibitor DS21150768 induces anti-tumor responses in multiple syngeneic tumor mouse models.
Setsu G, Goto M, Ito K, Taira T, Miyamoto M, Watanabe T, Taniguchi T, Umezaki Y, Nakazawa Y, Uesugi S, Mori K, Horiuchi T, Obuchi W, Minami M, Shimada T, Wada C, Yoshida T, Higuchi S.
Setsu G, et al.
Eur J Pharmacol. 2023 Dec 15;961:176184. doi: 10.1016/j.ejphar.2023.176184. Epub 2023 Nov 8.
Eur J Pharmacol. 2023.
PMID: 37944847
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Discovery of DS-9300: A Highly Potent, Selective, and Once-Daily Oral EP300/CBP Histone Acetyltransferase Inhibitor.
Kanada R, Kagoshima Y, Suzuki T, Nakamura A, Funami H, Watanabe J, Asano M, Takahashi M, Ubukata O, Suzuki K, Aikawa T, Sato K, Goto M, Setsu G, Ito K, Kihara K, Kuroha M, Kohno T, Ogiwara H, Isoyama T, Tominaga Y, Higuchi S, Naito H.
Kanada R, et al. Among authors: setsu g.
J Med Chem. 2023 Jan 12;66(1):695-715. doi: 10.1021/acs.jmedchem.2c01641. Epub 2022 Dec 26.
J Med Chem. 2023.
PMID: 36572866
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Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.
Yamaguchi Y, Murai I, Goto K, Doi S, Zhou H, Setsu G, Shimatani H, Okamura H, Miyake T, Doi M.
Yamaguchi Y, et al. Among authors: setsu g.
Sci Rep. 2021 Nov 17;11(1):22406. doi: 10.1038/s41598-021-01764-8.
Sci Rep. 2021.
PMID: 34789778
Free PMC article.
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Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176.
Wang T, Nakagawa S, Miyake T, Setsu G, Kunisue S, Goto K, Hirasawa A, Okamura H, Yamaguchi Y, Doi M.
Wang T, et al. Among authors: setsu g.
Sci Rep. 2020 Mar 10;10(1):4429. doi: 10.1038/s41598-020-61370-y.
Sci Rep. 2020.
PMID: 32157140
Free PMC article.
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Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour.
Doi M, Murai I, Kunisue S, Setsu G, Uchio N, Tanaka R, Kobayashi S, Shimatani H, Hayashi H, Chao HW, Nakagawa Y, Takahashi Y, Hotta Y, Yasunaga J, Matsuoka M, Hastings MH, Kiyonari H, Okamura H.
Doi M, et al. Among authors: setsu g.
Nat Commun. 2016 Feb 17;7:10583. doi: 10.1038/ncomms10583.
Nat Commun. 2016.
PMID: 26882873
Free PMC article.
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