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The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes.
Sesti G, Laratta E, Cardellini M, Andreozzi F, Del Guerra S, Irace C, Gnasso A, Grupillo M, Lauro R, Hribal ML, Perticone F, Marchetti P. Sesti G, et al. J Clin Endocrinol Metab. 2006 Jun;91(6):2334-9. doi: 10.1210/jc.2005-2323. Epub 2006 Apr 4. J Clin Endocrinol Metab. 2006. PMID: 16595597
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