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Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106.
J Med Chem. 2022 Jul 14;65(13):9206-9229. doi: 10.1021/acs.jmedchem.2c00403. Epub 2022 Jun 28.
J Med Chem. 2022.
PMID: 35763499
Identification of a Notch transcriptomic signature for breast cancer.
Braune EB, Geist F, Tang X, Kalari K, Boughey J, Wang L, Leon-Ferre RA, D'Assoro AB, Ingle JN, Goetz MP, Kreis J, Wang K, Foukakis T, Seshire A, Wienke D, Lendahl U.
Braune EB, et al. Among authors: seshire a.
Breast Cancer Res. 2024 Jan 3;26(1):4. doi: 10.1186/s13058-023-01757-7.
Breast Cancer Res. 2024.
PMID: 38172915
Free PMC article.
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Scalable Culture Strategies for the Expansion of Patient-Derived Cancer Stem Cell Lines.
Serra AT, Serra M, Silva AC, Brckalo T, Seshire A, Brito C, Wolf M, Alves PM.
Serra AT, et al. Among authors: seshire a.
Stem Cells Int. 2019 Feb 6;2019:8347595. doi: 10.1155/2019/8347595. eCollection 2019.
Stem Cells Int. 2019.
PMID: 30918523
Free PMC article.
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Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation.
Braune EB, Seshire A, Lendahl U.
Braune EB, et al. Among authors: seshire a.
Biomedicines. 2018 Nov 1;6(4):101. doi: 10.3390/biomedicines6040101.
Biomedicines. 2018.
PMID: 30388742
Free PMC article.
Review.
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Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter binding.
Seshire A, Rößiger T, Frech M, Beez S, Hagemeyer H, Puccetti E.
Seshire A, et al.
Leukemia. 2012 Jun;26(6):1338-47. doi: 10.1038/leu.2011.331. Epub 2011 Nov 22.
Leukemia. 2012.
PMID: 22105598
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Arsenic but not all-trans retinoic acid overcomes the aberrant stem cell capacity of PML/RARalpha-positive leukemic stem cells.
Zheng X, Seshire A, Rüster B, Bug G, Beissert T, Puccetti E, Hoelzer D, Henschler R, Ruthardt M.
Zheng X, et al. Among authors: seshire a.
Haematologica. 2007 Mar;92(3):323-31. doi: 10.3324/haematol.10541.
Haematologica. 2007.
PMID: 17339181
Free article.
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The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.
Puccetti E, Zheng X, Brambilla D, Seshire A, Beissert T, Boehrer S, Nürnberger H, Hoelzer D, Ottmann OG, Nervi C, Ruthardt M.
Puccetti E, et al. Among authors: seshire a.
Cancer Res. 2005 Jul 15;65(14):6080-8. doi: 10.1158/0008-5472.CAN-04-3631.
Cancer Res. 2005.
PMID: 16024608
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