Focused dampening of antibody response to the immunodominant variable loops by engineered soluble gp140.
Selvarajah S, Puffer BA, Lee FH, Zhu P, Li Y, Wyatt R, Roux KH, Doms RW, Burton DR.
Selvarajah S, et al.
AIDS Res Hum Retroviruses. 2008 Feb;24(2):301-14. doi: 10.1089/aid.2007.0158.
AIDS Res Hum Retroviruses. 2008.
PMID: 18284327
Immunization studies with modified gp120 monomers using a hyperglycosylation strategy, in which undesired epitopes are masked by the selective incorporation of N-linked glycans, were described in a previous paper (Selvarajah S, et al., J Virol 2000;79:12148-12163). …
Immunization studies with modified gp120 monomers using a hyperglycosylation strategy, in which undesired epitopes are masked by the selecti …