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Page 1
Molecular basis for substrate recruitment to the PRMT5 methylosome.
Mulvaney KM, Blomquist C, Acharya N, Li R, Ranaghan MJ, O'Keefe M, Rodriguez DJ, Young MJ, Kesar D, Pal D, Stokes M, Nelson AJ, Jain SS, Yang A, Mullin-Bernstein Z, Columbus J, Bozal FK, Skepner A, Raymond D, LaRussa S, McKinney DC, Freyzon Y, Baidi Y, Porter D, Aguirre AJ, Ianari A, McMillan B, Sellers WR. Mulvaney KM, et al. Among authors: sellers wr. Mol Cell. 2021 Sep 2;81(17):3481-3495.e7. doi: 10.1016/j.molcel.2021.07.019. Epub 2021 Aug 5. Mol Cell. 2021. PMID: 34358446 Free PMC article.
Molecular characterization of the tumor microenvironment in breast cancer.
Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K. Allinen M, et al. Among authors: sellers wr. Cancer Cell. 2004 Jul;6(1):17-32. doi: 10.1016/j.ccr.2004.06.010. Cancer Cell. 2004. PMID: 15261139 Free article.
ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor.
Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, Schoumacher M, Meyer R, Deeds J, Buchwalter G, Stams T, Keen N, Sellers WR, Brown M, Pagliarini RA. Mounir Z, et al. Among authors: sellers wr. Elife. 2016 May 16;5:e13964. doi: 10.7554/eLife.13964. Elife. 2016. PMID: 27183006 Free PMC article.
Quantitative Proteomics of the Cancer Cell Line Encyclopedia.
Nusinow DP, Szpyt J, Ghandi M, Rose CM, McDonald ER 3rd, Kalocsay M, Jané-Valbuena J, Gelfand E, Schweppe DK, Jedrychowski M, Golji J, Porter DA, Rejtar T, Wang YK, Kryukov GV, Stegmeier F, Erickson BK, Garraway LA, Sellers WR, Gygi SP. Nusinow DP, et al. Among authors: sellers wr. Cell. 2020 Jan 23;180(2):387-402.e16. doi: 10.1016/j.cell.2019.12.023. Cell. 2020. PMID: 31978347 Free PMC article.
Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35.
Atack TC, Raymond DD, Blomquist CA, Pasaje CF, McCarren PR, Moroco J, Befekadu HB, Robinson FP, Pal D, Esherick LY, Ianari A, Niles JC, Sellers WR. Atack TC, et al. Among authors: sellers wr. ACS Med Chem Lett. 2020 Sep 1;11(11):2131-2138. doi: 10.1021/acsmedchemlett.0c00272. eCollection 2020 Nov 12. ACS Med Chem Lett. 2020. PMID: 33209191 Free PMC article.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
McKinney DC, McMillan BJ, Ranaghan MJ, Moroco JA, Brousseau M, Mullin-Bernstein Z, O'Keefe M, McCarren P, Mesleh MF, Mulvaney KM, Robinson F, Singh R, Bajrami B, Wagner FF, Hilgraf R, Drysdale MJ, Campbell AJ, Skepner A, Timm DE, Porter D, Kaushik VK, Sellers WR, Ianari A. McKinney DC, et al. Among authors: sellers wr. J Med Chem. 2021 Aug 12;64(15):11148-11168. doi: 10.1021/acs.jmedchem.1c00507. Epub 2021 Aug 3. J Med Chem. 2021. PMID: 34342224 Free PMC article.
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
Ito T, Young MJ, Li R, Jain S, Wernitznig A, Krill-Burger JM, Lemke CT, Monducci D, Rodriguez DJ, Chang L, Dutta S, Pal D, Paolella BR, Rothberg MV, Root DE, Johannessen CM, Parida L, Getz G, Vazquez F, Doench JG, Zamanighomi M, Sellers WR. Ito T, et al. Among authors: sellers wr. Nat Genet. 2021 Dec;53(12):1664-1672. doi: 10.1038/s41588-021-00967-z. Epub 2021 Dec 2. Nat Genet. 2021. PMID: 34857952
Comparative optimization of combinatorial CRISPR screens.
Li R, Klingbeil O, Monducci D, Young MJ, Rodriguez DJ, Bayyat Z, Dempster JM, Kesar D, Yang X, Zamanighomi M, Vakoc CR, Ito T, Sellers WR. Li R, et al. Among authors: sellers wr. Nat Commun. 2022 May 5;13(1):2469. doi: 10.1038/s41467-022-30196-9. Nat Commun. 2022. PMID: 35513429 Free PMC article.
Systematic profiling of conditional degron tag technologies for target validation studies.
Bondeson DP, Mullin-Bernstein Z, Oliver S, Skipper TA, Atack TC, Bick N, Ching M, Guirguis AA, Kwon J, Langan C, Millson D, Paolella BR, Tran K, Wie SJ, Vazquez F, Tothova Z, Golub TR, Sellers WR, Ianari A. Bondeson DP, et al. Among authors: sellers wr. Nat Commun. 2022 Sep 20;13(1):5495. doi: 10.1038/s41467-022-33246-4. Nat Commun. 2022. PMID: 36127368 Free PMC article.
212 results