Segal DJ - Search Results

1

Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner.

O'Geen H, Bates SL, Carter SS, Nisson KA, Halmai J, Fink KD, Rhie SK, Farnham PJ, Segal DJ. O'Geen H, et al. Among authors: segal dj. Epigenetics Chromatin. 2019 May 3;12(1):26. doi: 10.1186/s13072-019-0275-8. Epigenetics Chromatin. 2019. PMID: 31053162 Free PMC article.

2

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture.

O'Geen H, Henry IM, Bhakta MS, Meckler JF, Segal DJ. O'Geen H, et al. Among authors: segal dj. Nucleic Acids Res. 2015 Mar 31;43(6):3389-404. doi: 10.1093/nar/gkv137. Epub 2015 Feb 20. Nucleic Acids Res. 2015. PMID: 25712100 Free PMC article.

3

How specific is CRISPR/Cas9 really?

O'Geen H, Yu AS, Segal DJ. O'Geen H, et al. Among authors: segal dj. Curr Opin Chem Biol. 2015 Dec;29:72-8. doi: 10.1016/j.cbpa.2015.10.001. Epub 2015 Oct 24. Curr Opin Chem Biol. 2015. PMID: 26517564 Free PMC article. Review.

4

Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain.

Bailus BJ, Pyles B, McAlister MM, O'Geen H, Lockwood SH, Adams AN, Nguyen JT, Yu A, Berman RF, Segal DJ. Bailus BJ, et al. Among authors: segal dj. Mol Ther. 2016 Mar;24(3):548-55. doi: 10.1038/mt.2015.236. Epub 2016 Jan 4. Mol Ther. 2016. PMID: 26727042 Free PMC article.

5

Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells.

Tak YG, Hung Y, Yao L, Grimmer MR, Do A, Bhakta MS, O'Geen H, Segal DJ, Farnham PJ. Tak YG, et al. Among authors: segal dj. Nucleic Acids Res. 2016 May 19;44(9):4123-33. doi: 10.1093/nar/gkv1530. Epub 2016 Jan 6. Nucleic Acids Res. 2016. PMID: 26743005 Free PMC article.

6

Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts.

Fink KD, Deng P, Gutierrez J, Anderson JS, Torrest A, Komarla A, Kalomoiris S, Cary W, Anderson JD, Gruenloh W, Duffy A, Tempkin T, Annett G, Wheelock V, Segal DJ, Nolta JA. Fink KD, et al. Among authors: segal dj. Cell Transplant. 2016;25(4):677-86. doi: 10.3727/096368916X690863. Epub 2016 Feb 4. Cell Transplant. 2016. PMID: 26850319 Free PMC article.

7

UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons.

Lopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike SI, Segal DJ, LaSalle JM. Lopez SJ, et al. Among authors: segal dj. Epigenetics. 2017;12(11):982-990. doi: 10.1080/15592294.2017.1376151. Epub 2017 Nov 6. Epigenetics. 2017. PMID: 28925810 Free PMC article.

8

dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression.

O'Geen H, Ren C, Nicolet CM, Perez AA, Halmai J, Le VM, Mackay JP, Farnham PJ, Segal DJ. O'Geen H, et al. Among authors: segal dj. Nucleic Acids Res. 2017 Sep 29;45(17):9901-9916. doi: 10.1093/nar/gkx578. Nucleic Acids Res. 2017. PMID: 28973434 Free PMC article.

9

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance.

Coggins NB, Stultz J, O'Geen H, Carvajal-Carmona LG, Segal DJ. Coggins NB, et al. Among authors: segal dj. Sci Rep. 2017 Nov 8;7(1):15044. doi: 10.1038/s41598-017-15407-4. Sci Rep. 2017. PMID: 29118424 Free PMC article.

10

Purified Protein Delivery to Activate an Epigenetically Silenced Allele in Mouse Brain.

Pyles B, Bailus BJ, O'Geen H, Segal DJ. Pyles B, et al. Among authors: segal dj. Methods Mol Biol. 2018;1767:227-239. doi: 10.1007/978-1-4939-7774-1_12. Methods Mol Biol. 2018. PMID: 29524138 Free PMC article.

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