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IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
Becker A, Eichentopf R, Sedlmeier R, Waniek A, Cynis H, Koch B, Stephan A, Bäuscher C, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, Plank AC, Roßner S, von Hörsten S, Graubner S, Demuth HU, Schilling S. Becker A, et al. Among authors: sedlmeier r. Biol Chem. 2016 Jan;397(1):45-55. doi: 10.1515/hsz-2015-0192. Biol Chem. 2016. PMID: 26351917
Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development.
Schilling S, Kohlmann S, Bäuscher C, Sedlmeier R, Koch B, Eichentopf R, Becker A, Cynis H, Hoffmann T, Berg S, Freyse EJ, von Hörsten S, Rossner S, Graubner S, Demuth HU. Schilling S, et al. Among authors: sedlmeier r. J Biol Chem. 2011 Apr 22;286(16):14199-208. doi: 10.1074/jbc.M111.229385. Epub 2011 Feb 17. J Biol Chem. 2011. PMID: 21330373 Free PMC article.
The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.
Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU. Cynis H, et al. Among authors: sedlmeier r. EMBO Mol Med. 2011 Sep;3(9):545-58. doi: 10.1002/emmm.201100158. Epub 2011 Jul 20. EMBO Mol Med. 2011. PMID: 21774078 Free PMC article.
Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.
Alexandru A, Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S. Alexandru A, et al. Among authors: sedlmeier r. J Neurosci. 2011 Sep 7;31(36):12790-801. doi: 10.1523/JNEUROSCI.1794-11.2011. J Neurosci. 2011. PMID: 21900558 Free PMC article.
Efficient and fast targeted production of murine models based on ENU mutagenesis.
Augustin M, Sedlmeier R, Peters T, Huffstadt U, Kochmann E, Simon D, Schöniger M, Garke-Mayerthaler S, Laufs J, Mayhaus M, Franke S, Klose M, Graupner A, Kurzmann M, Zinser C, Wolf A, Voelkel M, Kellner M, Kilian M, Seelig S, Koppius A, Teubner A, Korthaus D, Nehls M, Wattler S. Augustin M, et al. Among authors: sedlmeier r. Mamm Genome. 2005 Jun;16(6):405-13. doi: 10.1007/s00335-004-3028-2. Mamm Genome. 2005. PMID: 16075367
Alopecia in a novel mouse model RCO3 is caused by mK6irs1 deficiency.
Peters T, Sedlmeier R, Büssow H, Runkel F, Lüers GH, Korthaus D, Fuchs H, Hrabé de Angelis M, Stumm G, Russ AP, Porter RM, Augustin M, Franz T. Peters T, et al. Among authors: sedlmeier r. J Invest Dermatol. 2003 Oct;121(4):674-80. doi: 10.1046/j.1523-1747.2003.12491.x. J Invest Dermatol. 2003. PMID: 14632181 Free article.
N-ethyl-N-nitrosourea-based generation of mouse models for mutant G protein-coupled receptors.
Grosse J, Tarnow P, Römpler H, Schneider B, Sedlmeier R, Huffstadt U, Korthaus D, Nehls M, Wattler S, Schöneberg T, Biebermann H, Augustin M. Grosse J, et al. Among authors: sedlmeier r. Physiol Genomics. 2006 Aug 16;26(3):209-17. doi: 10.1152/physiolgenomics.00289.2005. Epub 2006 May 23. Physiol Genomics. 2006. PMID: 16720677 Free article.
Random mutagenesis in the mouse as a tool in drug discovery.
Russ A, Stumm G, Augustin M, Sedlmeier R, Wattler S, Nehls M. Russ A, et al. Among authors: sedlmeier r. Drug Discov Today. 2002 Dec 1;7(23):1175-83. doi: 10.1016/s1359-6446(02)02515-1. Drug Discov Today. 2002. PMID: 12547018 Review.
36 results