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A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder.
Kaldmäe M, Vosselman T, Zhong X, Lama D, Chen G, Saluri M, Kronqvist N, Siau JW, Ng AS, Ghadessy FJ, Sabatier P, Vojtesek B, Sarr M, Sahin C, Österlund N, Ilag LL, Väänänen VA, Sedimbi S, Arsenian-Henriksson M, Zubarev RA, Nilsson L, Koeck PJB, Rising A, Abelein A, Fritz N, Johansson J, Lane DP, Landreh M. Kaldmäe M, et al. Among authors: sedimbi s. Structure. 2022 May 5;30(5):733-742.e7. doi: 10.1016/j.str.2022.02.013. Epub 2022 Mar 14. Structure. 2022. PMID: 35290795 Free article.
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S. Ladds MJGW, et al. Among authors: sedimbi sk. Nat Commun. 2018 Mar 16;9(1):1107. doi: 10.1038/s41467-018-03441-3. Nat Commun. 2018. PMID: 29549331 Free PMC article.
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.
Ladds MJGW, van Leeuwen IMM, Drummond CJ, Chu S, Healy AR, Popova G, Pastor Fernández A, Mollick T, Darekar S, Sedimbi SK, Nekulova M, Sachweh MCC, Campbell J, Higgins M, Tuck C, Popa M, Safont MM, Gelebart P, Fandalyuk Z, Thompson AM, Svensson R, Gustavsson AL, Johansson L, Färnegårdh K, Yngve U, Saleh A, Haraldsson M, D'Hollander ACA, Franco M, Zhao Y, Håkansson M, Walse B, Larsson K, Peat EM, Pelechano V, Lunec J, Vojtesek B, Carmena M, Earnshaw WC, McCarthy AR, Westwood NJ, Arsenian-Henriksson M, Lane DP, Bhatia R, McCormack E, Laín S. Ladds MJGW, et al. Among authors: sedimbi sk. Nat Commun. 2018 May 22;9(1):2071. doi: 10.1038/s41467-018-04198-5. Nat Commun. 2018. PMID: 29789663 Free PMC article.
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells.
Eisinger S, Sarhan D, Boura VF, Ibarlucea-Benitez I, Tyystjärvi S, Oliynyk G, Arsenian-Henriksson M, Lane D, Wikström SL, Kiessling R, Virgilio T, Gonzalez SF, Kaczynska D, Kanatani S, Daskalaki E, Wheelock CE, Sedimbi S, Chambers BJ, Ravetch JV, Karlsson MCI. Eisinger S, et al. Among authors: sedimbi s. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):32005-32016. doi: 10.1073/pnas.2015343117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229588 Free PMC article.
The MDM2 Inhibitor Navtemadlin Arrests Mouse Melanoma Growth In Vivo and Potentiates Radiotherapy.
Ingelshed K, Spiegelberg D, Kannan P, Påvénius L, Hacheney J, Jiang L, Eisinger S, Lianoudaki D, Lama D, Castillo F, Bosdotter C, Kretzschmar WW, Al-Radi O, Fritz N, Villablanca EJ, Karlsson MCI, Wermeling F, Nestor M, Lane DP, Sedimbi SK. Ingelshed K, et al. Among authors: sedimbi sk. Cancer Res Commun. 2022 Sep 28;2(9):1075-1088. doi: 10.1158/2767-9764.CRC-22-0053. eCollection 2022 Sep. Cancer Res Commun. 2022. PMID: 36922937 Free PMC article.
Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses.
Sedimbi SK, Hägglöf T, Garimella MG, Wang S, Duhlin A, Coelho A, Ingelshed K, Mondoc E, Malin SG, Holmdahl R, Lane DP, Leadbetter EA, Karlsson MCI. Sedimbi SK, et al. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):9054-9063. doi: 10.1073/pnas.1920463117. Epub 2020 Apr 15. Proc Natl Acad Sci U S A. 2020. PMID: 32295878 Free PMC article.
Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells.
Kritikou JS, Oliveira MM, Record J, Saeed MB, Nigam SM, He M, Keszei M, Wagner AK, Brauner H, Sendel A, Sedimbi SK, Rentouli S, Lane DP, Snapper SB, Kärre K, Vandenberghe P, Orange JS, Westerberg LS. Kritikou JS, et al. Among authors: sedimbi sk. JCI Insight. 2021 Mar 22;6(6):e140273. doi: 10.1172/jci.insight.140273. JCI Insight. 2021. PMID: 33621210 Free PMC article.
IL-18 in inflammatory and autoimmune disease.
Sedimbi SK, Hägglöf T, Karlsson MC. Sedimbi SK, et al. Cell Mol Life Sci. 2013 Dec;70(24):4795-808. doi: 10.1007/s00018-013-1425-y. Epub 2013 Jul 27. Cell Mol Life Sci. 2013. PMID: 23892891 Review.
37 results