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A Stromal Lysolipid-Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression.
Auciello FR, Bulusu V, Oon C, Tait-Mulder J, Berry M, Bhattacharyya S, Tumanov S, Allen-Petersen BL, Link J, Kendsersky ND, Vringer E, Schug M, Novo D, Hwang RF, Evans RM, Nixon C, Dorrell C, Morton JP, Norman JC, Sears RC, Kamphorst JJ, Sherman MH. Auciello FR, et al. Among authors: sears rc. Cancer Discov. 2019 May;9(5):617-627. doi: 10.1158/2159-8290.CD-18-1212. Epub 2019 Mar 5. Cancer Discov. 2019. PMID: 30837243 Free PMC article.
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.
Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ. Ashton GH, et al. Among authors: sears rc. Dev Cell. 2010 Aug 17;19(2):259-69. doi: 10.1016/j.devcel.2010.07.015. Dev Cell. 2010. PMID: 20708588 Free PMC article.
A critical role for Mnt in Myc-driven T-cell proliferation and oncogenesis.
Link JM, Ota S, Zhou ZQ, Daniel CJ, Sears RC, Hurlin PJ. Link JM, et al. Among authors: sears rc. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19685-90. doi: 10.1073/pnas.1206406109. Epub 2012 Nov 12. Proc Natl Acad Sci U S A. 2012. PMID: 23150551 Free PMC article.
Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancer.
Farrell AS, Allen-Petersen B, Daniel CJ, Wang X, Wang Z, Rodriguez S, Impey S, Oddo J, Vitek MP, Lopez C, Christensen DJ, Sheppard B, Sears RC. Farrell AS, et al. Among authors: sears rc. Mol Cancer Res. 2014 Jun;12(6):924-39. doi: 10.1158/1541-7786.MCR-13-0542. Epub 2014 Mar 25. Mol Cancer Res. 2014. PMID: 24667985 Free PMC article.
Targeting c-MYC by antagonizing PP2A inhibitors in breast cancer.
Janghorban M, Farrell AS, Allen-Petersen BL, Pelz C, Daniel CJ, Oddo J, Langer EM, Christensen DJ, Sears RC. Janghorban M, et al. Among authors: sears rc. Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9157-62. doi: 10.1073/pnas.1317630111. Epub 2014 Jun 9. Proc Natl Acad Sci U S A. 2014. PMID: 24927563 Free PMC article.
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.
Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC. Farrell AS, et al. Among authors: sears rc. Nat Commun. 2017 Nov 23;8(1):1728. doi: 10.1038/s41467-017-01967-6. Nat Commun. 2017. PMID: 29170413 Free PMC article.
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer.
Risom T, Langer EM, Chapman MP, Rantala J, Fields AJ, Boniface C, Alvarez MJ, Kendsersky ND, Pelz CR, Johnson-Camacho K, Dobrolecki LE, Chin K, Aswani AJ, Wang NJ, Califano A, Lewis MT, Tomlin CJ, Spellman PT, Adey A, Gray JW, Sears RC. Risom T, et al. Among authors: sears rc. Nat Commun. 2018 Sep 19;9(1):3815. doi: 10.1038/s41467-018-05729-w. Nat Commun. 2018. PMID: 30232459 Free PMC article.
Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma.
Allen-Petersen BL, Risom T, Feng Z, Wang Z, Jenny ZP, Thoma MC, Pelz KR, Morton JP, Sansom OJ, Lopez CD, Sheppard B, Christensen DJ, Ohlmeyer M, Narla G, Sears RC. Allen-Petersen BL, et al. Among authors: sears rc. Cancer Res. 2019 Jan 1;79(1):209-219. doi: 10.1158/0008-5472.CAN-18-0717. Epub 2018 Nov 2. Cancer Res. 2019. PMID: 30389701 Free PMC article.
127 results