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Year Number of Results
2009 1
2012 3
2013 1
2014 3
2016 3
2017 4
2018 2
2019 3
2022 4
2023 3
2024 0

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Page 1
The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
Beaudoin JJ, Clemens L, Miedel MT, Gough A, Zaidi F, Ramamoorthy P, Wong KE, Sarangarajan R, Battista C, Shoda LKM, Siler SQ, Taylor DL, Howell BA, Vernetti LA, Yang K. Beaudoin JJ, et al. Among authors: siler sq. Int J Mol Sci. 2023 Jun 2;24(11):9692. doi: 10.3390/ijms24119692. Int J Mol Sci. 2023. PMID: 37298645 Free PMC article.
Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
Generaux G, Lakhani VV, Yang Y, Nadanaciva S, Qiu L, Riccardi K, Di L, Howell BA, Siler SQ, Watkins PB, Barton HA, Aleo MD, Shoda LKM. Generaux G, et al. Among authors: siler sq. Pharmacol Res Perspect. 2019 Oct 9;7(6):e00523. doi: 10.1002/prp2.523. eCollection 2019 Dec. Pharmacol Res Perspect. 2019. PMID: 31624633 Free PMC article. Clinical Trial.
Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
Longo DM, Woodhead JL, Walker P, Herédi-Szabó K, Mogyorósi K, Wolenski FS, Dragan YP, Mosedale M, Siler SQ, Watkins PB, Howell BA. Longo DM, et al. Among authors: siler sq. Toxicol Sci. 2019 Feb 1;167(2):458-467. doi: 10.1093/toxsci/kfy253. Toxicol Sci. 2019. PMID: 30289550 Free PMC article.
Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.
Woodhead JL, Paech F, Maurer M, Engelhardt M, Schmitt-Hoffmann AH, Spickermann J, Messner S, Wind M, Witschi AT, Krähenbühl S, Siler SQ, Watkins PB, Howell BA. Woodhead JL, et al. Among authors: siler sq. Clin Transl Sci. 2018 Sep;11(5):498-505. doi: 10.1111/cts.12560. Epub 2018 Jun 7. Clin Transl Sci. 2018. PMID: 29877622 Free PMC article.
22 results