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Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes.
Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneider F, Schmidt C, Yang M, Ehret S, Heine M, Jaeckstein MY, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Krüger M, Frezza C, Heeren J, Trifunovic A, Pasparakis M. Moschandrea C, et al. Among authors: schwarzer r. Nature. 2024 Jan;625(7994):385-392. doi: 10.1038/s41586-023-06857-0. Epub 2023 Dec 20. Nature. 2024. PMID: 38123683 Free PMC article.
Lipid signalling drives proteolytic rewiring of mitochondria by YME1L.
MacVicar T, Ohba Y, Nolte H, Mayer FC, Tatsuta T, Sprenger HG, Lindner B, Zhao Y, Li J, Bruns C, Krüger M, Habich M, Riemer J, Schwarzer R, Pasparakis M, Henschke S, Brüning JC, Zamboni N, Langer T. MacVicar T, et al. Among authors: schwarzer r. Nature. 2019 Nov;575(7782):361-365. doi: 10.1038/s41586-019-1738-6. Epub 2019 Nov 6. Nature. 2019. PMID: 31695197
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis.
Fritsch M, Günther SD, Schwarzer R, Albert MC, Schorn F, Werthenbach JP, Schiffmann LM, Stair N, Stocks H, Seeger JM, Lamkanfi M, Krönke M, Pasparakis M, Kashkar H. Fritsch M, et al. Among authors: schwarzer r. Nature. 2019 Nov;575(7784):683-687. doi: 10.1038/s41586-019-1770-6. Epub 2019 Nov 20. Nature. 2019. PMID: 31748744
A MAFG-lncRNA axis links systemic nutrient abundance to hepatic glucose metabolism.
Pradas-Juni M, Hansmeier NR, Link JC, Schmidt E, Larsen BD, Klemm P, Meola N, Topel H, Loureiro R, Dhaouadi I, Kiefer CA, Schwarzer R, Khani S, Oliverio M, Awazawa M, Frommolt P, Heeren J, Scheja L, Heine M, Dieterich C, Büning H, Yang L, Cao H, Jesus DF, Kulkarni RN, Zevnik B, Tröder SE, Knippschild U, Edwards PA, Lee RG, Yamamoto M, Ulitsky I, Fernandez-Rebollo E, Vallim TQA, Kornfeld JW. Pradas-Juni M, et al. Among authors: schwarzer r. Nat Commun. 2020 Jan 31;11(1):644. doi: 10.1038/s41467-020-14323-y. Nat Commun. 2020. PMID: 32005828 Free PMC article.
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation.
Jiao H, Wachsmuth L, Kumari S, Schwarzer R, Lin J, Eren RO, Fisher A, Lane R, Young GR, Kassiotis G, Kaiser WJ, Pasparakis M. Jiao H, et al. Among authors: schwarzer r. Nature. 2020 Apr;580(7803):391-395. doi: 10.1038/s41586-020-2129-8. Epub 2020 Mar 25. Nature. 2020. PMID: 32296175 Free PMC article.
319 results