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Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models.
Rosenke K, Jarvis MA, Feldmann F, Schwarz B, Okumura A, Lovaglio J, Saturday G, Hanley PW, Meade-White K, Williamson BN, Hansen F, Perez-Perez L, Leventhal S, Tang-Huau TL, Callison J, Haddock E, Stromberg KA, Scott D, Sewell G, Bosio CM, Hawman D, de Wit E, Feldmann H. Rosenke K, et al. Among authors: schwarz b. JCI Insight. 2020 Dec 3;5(23):e143174. doi: 10.1172/jci.insight.143174. JCI Insight. 2020. PMID: 33090972 Free PMC article.
Cutting Edge: Severe SARS-CoV-2 Infection in Humans Is Defined by a Shift in the Serum Lipidome, Resulting in Dysregulation of Eicosanoid Immune Mediators.
Schwarz B, Sharma L, Roberts L, Peng X, Bermejo S, Leighton I, Casanovas-Massana A, Minasyan M, Farhadian S, Ko AI; Yale IMPACT Team; Dela Cruz CS, Bosio CM. Schwarz B, et al. J Immunol. 2021 Jan 15;206(2):329-334. doi: 10.4049/jimmunol.2001025. Epub 2020 Dec 4. J Immunol. 2021. PMID: 33277388 Free PMC article. Clinical Trial.
Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model.
Rosenke K, Hansen F, Schwarz B, Feldmann F, Haddock E, Rosenke R, Barbian K, Meade-White K, Okumura A, Leventhal S, Hawman DW, Ricotta E, Bosio CM, Martens C, Saturday G, Feldmann H, Jarvis MA. Rosenke K, et al. Among authors: schwarz b. Nat Commun. 2021 Apr 16;12(1):2295. doi: 10.1038/s41467-021-22580-8. Nat Commun. 2021. PMID: 33863887 Free PMC article.
A genome-wide screen uncovers multiple roles for mitochondrial nucleoside diphosphate kinase D in inflammasome activation.
Ernst O, Sun J, Lin B, Banoth B, Dorrington MG, Liang J, Schwarz B, Stromberg KA, Katz S, Vayttaden SJ, Bradfield CJ, Slepushkina N, Rice CM, Buehler E, Khillan JS, McVicar DW, Bosio CM, Bryant CE, Sutterwala FS, Martin SE, Lal-Nag M, Fraser IDC. Ernst O, et al. Among authors: schwarz b. Sci Signal. 2021 Aug 3;14(694):eabe0387. doi: 10.1126/scisignal.abe0387. Sci Signal. 2021. PMID: 34344832 Free PMC article.
559 results