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Pharmacokinetic and Pharmacogenetic Markers of Irinotecan Toxicity.
Hahn RZ, Antunes MV, Verza SG, Perassolo MS, Suyenaga ES, Schwartsmann G, Linden R. Hahn RZ, et al. Among authors: schwartsmann g. Curr Med Chem. 2019;26(12):2085-2107. doi: 10.2174/0929867325666180622141101. Curr Med Chem. 2019. PMID: 29932028 Review.
Ultra-high performance liquid chromatography tandem mass spectrometric method for the determination of tamoxifen, N-desmethyltamoxifen, 4-hydroxytamoxifen and endoxifen in dried blood spots--development, validation and clinical application during breast cancer adjuvant therapy.
Antunes MV, Raymundo S, de Oliveira V, Staudt DE, Gössling G, Peteffi GP, Biazús JV, Cavalheiro JA, Tre-Hardy M, Capron A, Haufroid V, Wallemacq P, Schwartsmann G, Linden R. Antunes MV, et al. Among authors: schwartsmann g. Talanta. 2015 Jan;132:775-84. doi: 10.1016/j.talanta.2014.10.040. Epub 2014 Oct 29. Talanta. 2015. PMID: 25476377 Free article.
CYP3A4*22 is related to increased plasma levels of 4-hydroxytamoxifen and partially compensates for reduced CYP2D6 activation of tamoxifen.
Antunes MV, de Oliveira V, Raymundo S, Staudt DE, Gössling G, Biazús JV, Cavalheiro JA, Rosa DD, Mathy G, Wallemacq P, Linden R, Schwartsmann G, Haufroid V. Antunes MV, et al. Among authors: schwartsmann g. Pharmacogenomics. 2015;16(6):601-17. doi: 10.2217/pgs.15.13. Epub 2015 Apr 20. Pharmacogenomics. 2015. PMID: 25893704
Improved determination of uracil and dihydrouracil in plasma after a loading oral dose of uracil using high-performance liquid chromatography with photodiode array detection and porous graphitic carbon stationary phase.
Hahn RZ, Galarza AF, Schneider A, Antunes MV, Schwartsmann G, Linden R. Hahn RZ, et al. Among authors: schwartsmann g. Clin Biochem. 2015 Sep;48(13-14):915-8. doi: 10.1016/j.clinbiochem.2015.04.019. Epub 2015 May 1. Clin Biochem. 2015. PMID: 25940841
Endogenous plasma and salivary uracil to dihydrouracil ratios and DPYD genotyping as predictors of severe fluoropyrimidine toxicity in patients with gastrointestinal malignancies.
Galarza AF, Linden R, Antunes MV, Hahn RZ, Raymundo S, da Silva AC, Staggemeier R, Spilki FR, Schwartsmann G. Galarza AF, et al. Among authors: schwartsmann g. Clin Biochem. 2016 Nov;49(16-17):1221-1226. doi: 10.1016/j.clinbiochem.2016.07.004. Epub 2016 Jul 12. Clin Biochem. 2016. PMID: 27399164
Determination of irinotecan and its metabolite SN-38 in dried blood spots using high-performance liquid-chromatography with fluorescence detection.
Hahn RZ, Arnhold PC, Andriguetti NB, Schneider A, Klück HM, Dos Reis SL, Bastiani MF, Kael I, da Silva ACC, Schwartsmann G, Antunes MV, Linden R. Hahn RZ, et al. Among authors: schwartsmann g. J Pharm Biomed Anal. 2018 Feb 20;150:51-58. doi: 10.1016/j.jpba.2017.11.079. Epub 2017 Dec 5. J Pharm Biomed Anal. 2018. PMID: 29216585
Analytical and clinical validation of a dried blood spot assay for the determination of paclitaxel using high-performance liquid chromatography-tandem mass spectrometry.
Andriguetti NB, Hahn RZ, Lizot LF, Raymundo S, Costa JL, da Cunha KF, Vilela RMM, Kluck HM, Schwartsmann G, Antunes MV, Linden R. Andriguetti NB, et al. Among authors: schwartsmann g. Clin Biochem. 2018 Apr;54:123-130. doi: 10.1016/j.clinbiochem.2018.02.020. Epub 2018 Mar 4. Clin Biochem. 2018. PMID: 29514052
DPD functional tests in plasma, fresh saliva and dried saliva samples as predictors of 5-fluorouracil exposure and occurrence of drug-related severe toxicity.
Neto OV, Raymundo S, Franzoi MA, do Carmo Artmann A, Tegner M, Müller VV, Hahn RZ, Alves GV, Schwartsmann G, Linden R, Antunes MV. Neto OV, et al. Among authors: schwartsmann g. Clin Biochem. 2018 Jun;56:18-25. doi: 10.1016/j.clinbiochem.2018.04.001. Epub 2018 Apr 4. Clin Biochem. 2018. PMID: 29625079
256 results