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Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation.
Albers HM, Dong A, van Meeteren LA, Egan DA, Sunkara M, van Tilburg EW, Schuurman K, van Tellingen O, Morris AJ, Smyth SS, Moolenaar WH, Ovaa H. Albers HM, et al. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7257-62. doi: 10.1073/pnas.1001529107. Epub 2010 Apr 1. Proc Natl Acad Sci U S A. 2010. PMID: 20360563 Free PMC article.
Fluorescence-based proteasome activity profiling.
de Jong A, Schuurman KG, Rodenko B, Ovaa H, Berkers CR. de Jong A, et al. Among authors: schuurman kg. Methods Mol Biol. 2012;803:183-204. doi: 10.1007/978-1-61779-364-6_13. Methods Mol Biol. 2012. PMID: 22065226
Proteasome Activation by Small Molecules.
Leestemaker Y, de Jong A, Witting KF, Penning R, Schuurman K, Rodenko B, Zaal EA, van de Kooij B, Laufer S, Heck AJR, Borst J, Scheper W, Berkers CR, Ovaa H. Leestemaker Y, et al. Cell Chem Biol. 2017 Jun 22;24(6):725-736.e7. doi: 10.1016/j.chembiol.2017.05.010. Epub 2017 May 25. Cell Chem Biol. 2017. PMID: 28552582 Free article.
FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome.
Schrijver W, Schuurman K, van Rossum A, Droog M, Jeronimo C, Salta S, Henrique R, Wesseling J, Moelans C, Linn SC, van den Heuvel M, van Diest P, Zwart W. Schrijver W, et al. Mol Oncol. 2018 Nov;12(11):1884-1894. doi: 10.1002/1878-0261.12353. Epub 2018 Oct 12. Mol Oncol. 2018. PMID: 29972720 Free PMC article. Clinical Trial.
32 results