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G6b-B regulates an essential step in megakaryocyte maturation.
Becker IC, Nagy Z, Manukjan G, Haffner-Luntzer M, Englert M, Heib T, Vögtle T, Gross C, Bharti R, Dietrich S, Mott K, Heck J, Stegmaier S, Baranowsky A, Schinke T, Schlegel N, Heckel T, Stegner D, Pleines I, Ignatius A, Schulze H, Nieswandt B. Becker IC, et al. Among authors: schulze h. Blood Adv. 2022 May 24;6(10):3155-3161. doi: 10.1182/bloodadvances.2021006151. Blood Adv. 2022. PMID: 35134123 Free PMC article.
Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.
Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. Bender M, et al. Among authors: schulze h. Nat Commun. 2014 Sep 4;5:4746. doi: 10.1038/ncomms5746. Nat Commun. 2014. PMID: 25187265 Free article.
Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture.
Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. Stritt S, et al. Among authors: schulze h. Nat Commun. 2016 Mar 29;7:11097. doi: 10.1038/ncomms11097. Nat Commun. 2016. PMID: 27020697 Free PMC article.
Recessive grey platelet-like syndrome with unaffected erythropoiesis in the absence of the splice isoform GFI1B-p37.
Schulze H, Schlagenhauf A, Manukjan G, Beham-Schmid C, Andres O, Klopocki E, König EM, Haidl H, Panzer S, Althaus K, Muntean WE, Schwinger W, Urban C, Greinacher A, Bakchoul T, Seidel MG. Schulze H, et al. Haematologica. 2017 Sep;102(9):e375-e378. doi: 10.3324/haematol.2017.167957. Epub 2017 May 26. Haematologica. 2017. PMID: 28550182 Free PMC article. No abstract available.
A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis.
Dütting S, Gaits-Iacovoni F, Stegner D, Popp M, Antkowiak A, van Eeuwijk JMM, Nurden P, Stritt S, Heib T, Aurbach K, Angay O, Cherpokova D, Heinz N, Baig AA, Gorelashvili MG, Gerner F, Heinze KG, Ware J, Krohne G, Ruggeri ZM, Nurden AT, Schulze H, Modlich U, Pleines I, Brakebusch C, Nieswandt B. Dütting S, et al. Among authors: schulze h. Nat Commun. 2017 Jun 15;8:15838. doi: 10.1038/ncomms15838. Nat Commun. 2017. PMID: 28643773 Free PMC article.
Thrombopoiesis is spatially regulated by the bone marrow vasculature.
Stegner D, vanEeuwijk JMM, Angay O, Gorelashvili MG, Semeniak D, Pinnecker J, Schmithausen P, Meyer I, Friedrich M, Dütting S, Brede C, Beilhack A, Schulze H, Nieswandt B, Heinze KG. Stegner D, et al. Among authors: schulze h. Nat Commun. 2017 Jul 25;8(1):127. doi: 10.1038/s41467-017-00201-7. Nat Commun. 2017. PMID: 28743899 Free PMC article.
966 results