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AA-amyloidosis in cats (Felis catus) housed in shelters.
Ferri F, Ferro S, Porporato F, Callegari C, Guglielmetti C, Mazza M, Ferrero M, Crinò C, Gallo E, Drigo M, Coppola LM, Gerardi G, Schulte TP, Ricagno S, Vogel M, Storni F, Bachmann MF, Vogt AC, Caminito S, Mazzini G, Lavatelli F, Palladini G, Merlini G, Zini E. Ferri F, et al. Among authors: schulte tp. PLoS One. 2023 Mar 29;18(3):e0281822. doi: 10.1371/journal.pone.0281822. eCollection 2023. PLoS One. 2023. PMID: 36989207 Free PMC article.
Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation.
Broggini L, Barzago MM, Speranzini V, Schulte T, Sonzini F, Giono M, Romeo M, Milani P, Caminito S, Mazzini G, Rognoni P, Merlini G, Pappone C, Anastasia L, Nuvolone M, Palladini G, Diomede L, Ricagno S. Broggini L, et al. J Mol Biol. 2023 Dec 15;435(24):168320. doi: 10.1016/j.jmb.2023.168320. Epub 2023 Oct 20. J Mol Biol. 2023. PMID: 37865287
The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with CXCL12.
Mantonico MV, De Leo F, Quilici G, Colley LS, De Marchis F, Crippa M, Mezzapelle R, Schulte T, Zucchelli C, Pastorello C, Carmeno C, Caprioglio F, Ricagno S, Giachin G, Ghitti M, Bianchi ME, Musco G. Mantonico MV, et al. Nat Commun. 2024 Feb 8;15(1):1201. doi: 10.1038/s41467-024-45505-7. Nat Commun. 2024. PMID: 38331917 Free PMC article.