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Activity-Based Imaging of Acid Ceramidase in Living Cells.
Ordóñez YF, Abad JL, Aseeri M, Casas J, Garcia V, Casasampere M, Schuchman EH, Levade T, Delgado A, Triola G, Fabrias G. Ordóñez YF, et al. Among authors: schuchman eh. J Am Chem Soc. 2019 May 15;141(19):7736-7742. doi: 10.1021/jacs.8b11687. Epub 2019 May 2. J Am Chem Soc. 2019. PMID: 31030513
The reverse activity of human acid ceramidase.
Okino N, He X, Gatt S, Sandhoff K, Ito M, Schuchman EH. Okino N, et al. Among authors: schuchman eh. J Biol Chem. 2003 Aug 8;278(32):29948-53. doi: 10.1074/jbc.M303310200. Epub 2003 May 22. J Biol Chem. 2003. PMID: 12764132 Free article.
Autoproteolytic cleavage and activation of human acid ceramidase.
Shtraizent N, Eliyahu E, Park JH, He X, Shalgi R, Schuchman EH. Shtraizent N, et al. Among authors: schuchman eh. J Biol Chem. 2008 Apr 25;283(17):11253-9. doi: 10.1074/jbc.M709166200. Epub 2008 Feb 14. J Biol Chem. 2008. PMID: 18281275 Free PMC article.
Identification of cystatin SA as a novel inhibitor of acid ceramidase.
Eliyahu E, Shtraizent N, He X, Chen D, Shalgi R, Schuchman EH. Eliyahu E, et al. Among authors: schuchman eh. J Biol Chem. 2011 Oct 14;286(41):35624-35633. doi: 10.1074/jbc.M111.260372. Epub 2011 Aug 16. J Biol Chem. 2011. PMID: 21846728 Free PMC article.
Acid ceramidase maintains the chondrogenic phenotype of expanded primary chondrocytes and improves the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells.
Simonaro CM, Sachot S, Ge Y, He X, Deangelis VA, Eliyahu E, Leong DJ, Sun HB, Mason JB, Haskins ME, Richardson DW, Schuchman EH. Simonaro CM, et al. Among authors: schuchman eh. PLoS One. 2013 Apr 26;8(4):e62715. doi: 10.1371/journal.pone.0062715. Print 2013. PLoS One. 2013. PMID: 23638138 Free PMC article.
Systemic ceramide accumulation leads to severe and varied pathological consequences.
Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA. Alayoubi AM, et al. Among authors: schuchman eh. EMBO Mol Med. 2013 Jun;5(6):827-42. doi: 10.1002/emmm.201202301. Epub 2013 May 16. EMBO Mol Med. 2013. PMID: 23681708 Free PMC article.
240 results