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Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss.
Rodriguez S, Sahin A, Schrank BR, Al-Lawati H, Costantino I, Benz E, Fard D, Albers AD, Cao L, Gomez AC, Evans K, Ratti E, Cudkowicz M, Frosch MP, Talkowski M, Sorger PK, Hyman BT, Albers MW. Rodriguez S, et al. Among authors: schrank br. Sci Transl Med. 2021 Jul 7;13(601):eaaz4699. doi: 10.1126/scitranslmed.aaz4699. Sci Transl Med. 2021. PMID: 34233951 Free PMC article.
Intradermally delivered mRNA-encapsulating extracellular vesicles for collagen-replacement therapy.
You Y, Tian Y, Yang Z, Shi J, Kwak KJ, Tong Y, Estania AP, Cao J, Hsu WH, Liu Y, Chiang CL, Schrank BR, Huntoon K, Lee D, Li Z, Zhao Y, Zhang H, Gallup TD, Ha J, Dong S, Li X, Wang Y, Lu WJ, Bahrani E, Lee LJ, Teng L, Jiang W, Lan F, Kim BYS, Lee AS. You Y, et al. Among authors: schrank br. Nat Biomed Eng. 2023 Jul;7(7):887-900. doi: 10.1038/s41551-022-00989-w. Epub 2023 Jan 12. Nat Biomed Eng. 2023. PMID: 36635419
Age-associated disparity in phagocytic clearance affects the efficacy of cancer nanotherapeutics.
Wang Y, Deng W, Lee D, Yan L, Lu Y, Dong S, Huntoon K, Antony A, Li X, Ye R, Zhao Y, Zhao F, Schrank BR, Ha J, Kang M, Yang M, Gong P, Lorenzi PL, Tan L, Gallup TD, Tang SK, Yang Z, Li J, Sanford NN, Wang H, Kim BYS, Jiang W. Wang Y, et al. Among authors: schrank br. Nat Nanotechnol. 2024 Feb;19(2):255-263. doi: 10.1038/s41565-023-01502-3. Epub 2023 Sep 18. Nat Nanotechnol. 2024. PMID: 37723279
Adaptive design of mRNA-loaded extracellular vesicles for targeted immunotherapy of cancer.
Dong S, Liu X, Bi Y, Wang Y, Antony A, Lee D, Huntoon K, Jeong S, Ma Y, Li X, Deng W, Schrank BR, Grippin AJ, Ha J, Kang M, Chang M, Zhao Y, Sun R, Sun X, Yang J, Chen J, Tang SK, Lee LJ, Lee AS, Teng L, Wang S, Teng L, Kim BYS, Yang Z, Jiang W. Dong S, et al. Among authors: schrank br. Nat Commun. 2023 Oct 19;14(1):6610. doi: 10.1038/s41467-023-42365-5. Nat Commun. 2023. PMID: 37857647 Free PMC article.
Synthetic cationic helical polypeptides for the stimulation of antitumour innate immune pathways in antigen-presenting cells.
Lee D, Huntoon K, Wang Y, Kang M, Lu Y, Jeong SD, Link TM, Gallup TD, Qie Y, Li X, Dong S, Schrank BR, Grippin AJ, Antony A, Ha J, Chang M, An Y, Wang L, Jiang D, Li J, Koong AC, Tainer JA, Jiang W, Kim BYS. Lee D, et al. Among authors: schrank br. Nat Biomed Eng. 2024 Apr 19. doi: 10.1038/s41551-024-01194-7. Online ahead of print. Nat Biomed Eng. 2024. PMID: 38641710
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization.
Zagelbaum J, Schooley A, Zhao J, Schrank BR, Callen E, Zha S, Gottesman ME, Nussenzweig A, Rabadan R, Dekker J, Gautier J. Zagelbaum J, et al. Among authors: schrank br. Nat Struct Mol Biol. 2023 Jan;30(1):99-106. doi: 10.1038/s41594-022-00893-6. Epub 2022 Dec 23. Nat Struct Mol Biol. 2023. PMID: 36564591 Free PMC article.
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