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The Fungal Cyp51 Inhibitor VT-1129 Is Efficacious in an Experimental Model of Cryptococcal Meningitis.
Wiederhold NP, Najvar LK, Garvey EP, Brand SR, Xu X, Ottinger EA, Alimardanov A, Cradock J, Behnke M, Hoekstra WJ, Schotzinger RJ, Jaramillo R, Olivo M, Kirkpatrick WR, Patterson TF. Wiederhold NP, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e01071-18. doi: 10.1128/AAC.01071-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29987152 Free PMC article.
Fungal CYP51 Inhibitors VT-1161 and VT-1129 Exhibit Strong In Vitro Activity against Candida glabrata and C. krusei Isolates Clinically Resistant to Azole and Echinocandin Antifungal Compounds.
Schell WA, Jones AM, Garvey EP, Hoekstra WJ, Schotzinger RJ, Alexander BD. Schell WA, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2017 Feb 23;61(3):e01817-16. doi: 10.1128/AAC.01817-16. Print 2017 Mar. Antimicrob Agents Chemother. 2017. PMID: 27956419 Free PMC article.
In Vivo Efficacy of VT-1129 against Experimental Cryptococcal Meningitis with the Use of a Loading Dose-Maintenance Dose Administration Strategy.
Wiederhold NP, Xu X, Wang A, Najvar LK, Garvey EP, Ottinger EA, Alimardanov A, Cradock J, Behnke M, Hoekstra WJ, Brand SR, Schotzinger RJ, Jaramillo R, Olivo M, Kirkpatrick WR, Patterson TF. Wiederhold NP, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2018 Oct 24;62(11):e01315-18. doi: 10.1128/AAC.01315-18. Print 2018 Nov. Antimicrob Agents Chemother. 2018. PMID: 30104280 Free PMC article.
The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris.
Wiederhold NP, Lockhart SR, Najvar LK, Berkow EL, Jaramillo R, Olivo M, Garvey EP, Yates CM, Schotzinger RJ, Catano G, Patterson TF. Wiederhold NP, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2019 Feb 26;63(3):e02233-18. doi: 10.1128/AAC.02233-18. Print 2019 Mar. Antimicrob Agents Chemother. 2019. PMID: 30530603 Free PMC article.
In Vitro Activities of the Novel Investigational Tetrazoles VT-1161 and VT-1598 Compared to the Triazole Antifungals against Azole-Resistant Strains and Clinical Isolates of Candida albicans.
Nishimoto AT, Wiederhold NP, Flowers SA, Zhang Q, Kelly SL, Morschhäuser J, Yates CM, Hoekstra WJ, Schotzinger RJ, Garvey EP, Rogers PD. Nishimoto AT, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2019 May 24;63(6):e00341-19. doi: 10.1128/AAC.00341-19. Print 2019 Jun. Antimicrob Agents Chemother. 2019. PMID: 30910896 Free PMC article.
Impact of the Major Candida glabrata Triazole Resistance Determinants on the Activity of the Novel Investigational Tetrazoles VT-1598 and VT-1161.
Nishimoto AT, Whaley SG, Wiederhold NP, Zhang Q, Yates CM, Hoekstra WJ, Schotzinger RJ, Garvey EP, Rogers PD. Nishimoto AT, et al. Among authors: schotzinger rj. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01304-19. doi: 10.1128/AAC.01304-19. Print 2019 Oct. Antimicrob Agents Chemother. 2019. PMID: 31383660 Free PMC article.
37 results