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Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling.
De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau É, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM. De Souza DC, et al. Among authors: schonbrun e. Nat Commun. 2023 Sep 20;14(1):5850. doi: 10.1038/s41467-023-40923-5. Nat Commun. 2023. PMID: 37730674 Free PMC article.
MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease.
Demers M, Sturtevant S, Guertin KR, Gupta D, Desai K, Vieira BF, Li W, Hicks A, Ismail A, Gonçalves BP, Di Caprio G, Schonbrun E, Hansen S, Musayev FN, Safo MK, Wood DK, Higgins JM, Light DR. Demers M, et al. Among authors: schonbrun e. Blood Adv. 2021 Mar 9;5(5):1388-1402. doi: 10.1182/bloodadvances.2020003670. Blood Adv. 2021. PMID: 33661300 Free PMC article.
Microscopy, Meet Big Data.
Orth A, Schaak D, Schonbrun E. Orth A, et al. Among authors: schonbrun e. Cell Syst. 2017 Mar 22;4(3):260-261. doi: 10.1016/j.cels.2017.03.009. Cell Syst. 2017. PMID: 28334574 Free article.
Dictionary-enhanced imaging cytometry.
Orth A, Schaak D, Schonbrun E. Orth A, et al. Among authors: schonbrun e. Sci Rep. 2017 Feb 22;7:43148. doi: 10.1038/srep43148. Sci Rep. 2017. PMID: 28225061 Free PMC article.
Single-cell measurement of red blood cell oxygen affinity.
Di Caprio G, Stokes C, Higgins JM, Schonbrun E. Di Caprio G, et al. Among authors: schonbrun e. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9984-9. doi: 10.1073/pnas.1509252112. Epub 2015 Jul 27. Proc Natl Acad Sci U S A. 2015. PMID: 26216973 Free PMC article.
37 results