Schofield CJ - Search Results

1

First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53.

Nowak RP, Tumber A, Hendrix E, Ansari MSZ, Sabatino M, Antonini L, Andrijes R, Salah E, Mautone N, Pellegrini FR, Simelis K, Kawamura A, Johansson C, Passeri D, Pellicciari R, Ciogli A, Del Bufalo D, Ragno R, Coleman ML, Trisciuoglio D, Mai A, Oppermann U, Schofield CJ, Rotili D. Nowak RP, et al. Among authors: schofield cj. J Med Chem. 2021 Dec 9;64(23):17031-17050. doi: 10.1021/acs.jmedchem.1c00605. Epub 2021 Nov 29. J Med Chem. 2021. PMID: 34843649 Free PMC article.

2

Mass spectrometry reveals elastase inhibitors from the reactive centre loop of alpha1-antitrypsin.

Wright PA, Rostom AA, Robinson CV, Schofield CJ. Wright PA, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1219-21. doi: 10.1016/s0960-894x(00)00194-3. Bioorg Med Chem Lett. 2000. PMID: 10866385

3

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.

Mole DR, Schlemminger I, McNeill LA, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Mole DR, et al. Among authors: schofield cj. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2677-80. doi: 10.1016/s0960-894x(03)00539-0. Bioorg Med Chem Lett. 2003. PMID: 12873492

4

Crystal structure and mechanistic implications of 1-aminocyclopropane-1-carboxylic acid oxidase--the ethylene-forming enzyme.

Zhang Z, Ren JS, Clifton IJ, Schofield CJ. Zhang Z, et al. Among authors: schofield cj. Chem Biol. 2004 Oct;11(10):1383-94. doi: 10.1016/j.chembiol.2004.08.012. Chem Biol. 2004. PMID: 15489165

5

Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease.

McDonough MA, Kavanagh KL, Butler D, Searls T, Oppermann U, Schofield CJ. McDonough MA, et al. Among authors: schofield cj. J Biol Chem. 2005 Dec 9;280(49):41101-10. doi: 10.1074/jbc.M507528200. Epub 2005 Sep 25. J Biol Chem. 2005. PMID: 16186124 Free article.

6

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.

Coleman ML, McDonough MA, Hewitson KS, Coles C, Mecinovic J, Edelmann M, Cook KM, Cockman ME, Lancaster DE, Kessler BM, Oldham NJ, Ratcliffe PJ, Schofield CJ. Coleman ML, et al. Among authors: schofield cj. J Biol Chem. 2007 Aug 17;282(33):24027-38. doi: 10.1074/jbc.M704102200. Epub 2007 Jun 15. J Biol Chem. 2007. PMID: 17573339 Free article.

7

Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

Ng SS, Kavanagh KL, McDonough MA, Butler D, Pilka ES, Lienard BM, Bray JE, Savitsky P, Gileadi O, von Delft F, Rose NR, Offer J, Scheinost JC, Borowski T, Sundstrom M, Schofield CJ, Oppermann U. Ng SS, et al. Among authors: schofield cj. Nature. 2007 Jul 5;448(7149):87-91. doi: 10.1038/nature05971. Epub 2007 Jun 24. Nature. 2007. PMID: 17589501

8

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.

Rose NR, Ng SS, Mecinović J, Liénard BM, Bello SH, Sun Z, McDonough MA, Oppermann U, Schofield CJ. Rose NR, et al. Among authors: schofield cj. J Med Chem. 2008 Nov 27;51(22):7053-6. doi: 10.1021/jm800936s. J Med Chem. 2008. PMID: 18942826

9

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold.

Kelly L, McDonough MA, Coleman ML, Ratcliffe PJ, Schofield CJ. Kelly L, et al. Among authors: schofield cj. Mol Biosyst. 2009 Jan;5(1):52-8. doi: 10.1039/b815271c. Epub 2008 Oct 29. Mol Biosyst. 2009. PMID: 19081931

10

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

Stubbs CJ, Loenarz C, Mecinović J, Yeoh KK, Hindley N, Liénard BM, Sobott F, Schofield CJ, Flashman E. Stubbs CJ, et al. Among authors: schofield cj. J Med Chem. 2009 May 14;52(9):2799-805. doi: 10.1021/jm900285r. J Med Chem. 2009. PMID: 19364117

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