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Deletion of TAK1 in the myeloid lineage results in the spontaneous development of myelomonocytic leukemia in mice.
Lamothe B, Lai Y, Hur L, Orozco NM, Wang J, Campos AD, Xie M, Schneider MD, Lockworth CR, Jakacky J, Tran D, Ho M, Dawud S, Dong C, Lin HK, Hu P, Estrov Z, Bueso-Ramos CE, Darnay BG. Lamothe B, et al. Among authors: schneider md. PLoS One. 2012;7(12):e51228. doi: 10.1371/journal.pone.0051228. Epub 2012 Dec 10. PLoS One. 2012. PMID: 23251462 Free PMC article.
Essential role of TAK1 in thymocyte development and activation.
Liu HH, Xie M, Schneider MD, Chen ZJ. Liu HH, et al. Among authors: schneider md. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11677-82. doi: 10.1073/pnas.0603089103. Epub 2006 Jul 20. Proc Natl Acad Sci U S A. 2006. PMID: 16857737 Free PMC article.
Microtubules regulate focal adhesion dynamics through MAP4K4.
Yue J, Xie M, Gou X, Lee P, Schneider MD, Wu X. Yue J, et al. Among authors: schneider md. Dev Cell. 2014 Dec 8;31(5):572-85. doi: 10.1016/j.devcel.2014.10.025. Dev Cell. 2014. PMID: 25490267 Free PMC article.
Phosphorylation of Thr-178 and Thr-184 in the TAK1 T-loop is required for interleukin (IL)-1-mediated optimal NFkappaB and AP-1 activation as well as IL-6 gene expression.
Yu Y, Ge N, Xie M, Sun W, Burlingame S, Pass AK, Nuchtern JG, Zhang D, Fu S, Schneider MD, Fan J, Yang J. Yu Y, et al. Among authors: schneider md. J Biol Chem. 2008 Sep 5;283(36):24497-505. doi: 10.1074/jbc.M802825200. Epub 2008 Jul 10. J Biol Chem. 2008. PMID: 18617512 Free PMC article.
TAK1 is an essential regulator of BMP signalling in cartilage.
Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH. Shim JH, et al. Among authors: schneider md. EMBO J. 2009 Jul 22;28(14):2028-41. doi: 10.1038/emboj.2009.162. Epub 2009 Jun 18. EMBO J. 2009. PMID: 19536134 Free PMC article.
293 results