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LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs.
Augustyn E, Finke K, Zur AA, Hansen L, Heeren N, Chien HC, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. Augustyn E, et al. Among authors: schlessinger a. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2616-2621. doi: 10.1016/j.bmcl.2016.04.023. Epub 2016 Apr 11. Bioorg Med Chem Lett. 2016. PMID: 27106710 Free PMC article.
LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.
Zur AA, Chien HC, Augustyn E, Flint A, Heeren N, Finke K, Hernandez C, Hansen L, Miller S, Lin L, Giacomini KM, Colas C, Schlessinger A, Thomas AA. Zur AA, et al. Among authors: schlessinger a. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5000-5006. doi: 10.1016/j.bmcl.2016.09.001. Epub 2016 Sep 3. Bioorg Med Chem Lett. 2016. PMID: 27624080 Free PMC article.
Reevaluating the Substrate Specificity of the L-Type Amino Acid Transporter (LAT1).
Chien HC, Colas C, Finke K, Springer S, Stoner L, Zur AA, Venteicher B, Campbell J, Hall C, Flint A, Augustyn E, Hernandez C, Heeren N, Hansen L, Anthony A, Bauer J, Fotiadis D, Schlessinger A, Giacomini KM, Thomas AA. Chien HC, et al. Among authors: schlessinger a. J Med Chem. 2018 Aug 23;61(16):7358-7373. doi: 10.1021/acs.jmedchem.8b01007. Epub 2018 Aug 10. J Med Chem. 2018. PMID: 30048132 Free PMC article.
Functional genomics of OCTN2 variants informs protein-specific variant effect predictor for Carnitine Transporter Deficiency.
Koleske ML, McInnes G, Brown JEH, Thomas N, Hutchinson K, Chin MY, Koehl A, Arkin MR, Schlessinger A, Gallagher RC, Song YS, Altman RB, Giacomini KM. Koleske ML, et al. Among authors: schlessinger a. Proc Natl Acad Sci U S A. 2022 Nov 16;119(46):e2210247119. doi: 10.1073/pnas.2210247119. Epub 2022 Nov 7. Proc Natl Acad Sci U S A. 2022. PMID: 36343260 Free PMC article.
Conserved allosteric inhibition mechanism in SLC1 transporters.
Dong Y, Wang J, Garibsingh RA, Hutchinson K, Shi Y, Eisenberg G, Yu X, Schlessinger A, Grewer C. Dong Y, et al. Among authors: schlessinger a. Elife. 2023 Mar 1;12:e83464. doi: 10.7554/eLife.83464. Elife. 2023. PMID: 36856089 Free PMC article.
110 results