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5'-Triphosphate RNA is the ligand for RIG-I.
Hornung V, Ellegast J, Kim S, Brzózka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G. Hornung V, et al. Among authors: schlee m. Science. 2006 Nov 10;314(5801):994-7. doi: 10.1126/science.1132505. Epub 2006 Oct 12. Science. 2006. PMID: 17038590
siRNA and isRNA: two edges of one sword.
Schlee M, Hornung V, Hartmann G. Schlee M, et al. Mol Ther. 2006 Oct;14(4):463-70. doi: 10.1016/j.ymthe.2006.06.001. Epub 2006 Jul 31. Mol Ther. 2006. PMID: 16877044 Free article. Review.
RNA recognition via TLR7 and TLR8.
Hornung V, Barchet W, Schlee M, Hartmann G. Hornung V, et al. Among authors: schlee m. Handb Exp Pharmacol. 2008;(183):71-86. doi: 10.1007/978-3-540-72167-3_4. Handb Exp Pharmacol. 2008. PMID: 18071655 Review.
Approaching the RNA ligand for RIG-I?
Schlee M, Hartmann E, Coch C, Wimmenauer V, Janke M, Barchet W, Hartmann G. Schlee M, et al. Immunol Rev. 2009 Jan;227(1):66-74. doi: 10.1111/j.1600-065X.2008.00724.x. Immunol Rev. 2009. PMID: 19120476 Review.
Selection of molecular structure and delivery of RNA oligonucleotides to activate TLR7 versus TLR8 and to induce high amounts of IL-12p70 in primary human monocytes.
Ablasser A, Poeck H, Anz D, Berger M, Schlee M, Kim S, Bourquin C, Goutagny N, Jiang Z, Fitzgerald KA, Rothenfusser S, Endres S, Hartmann G, Hornung V. Ablasser A, et al. Among authors: schlee m. J Immunol. 2009 Jun 1;182(11):6824-33. doi: 10.4049/jimmunol.0803001. J Immunol. 2009. PMID: 19454678
Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus.
Schlee M, Roth A, Hornung V, Hagmann CA, Wimmenauer V, Barchet W, Coch C, Janke M, Mihailovic A, Wardle G, Juranek S, Kato H, Kawai T, Poeck H, Fitzgerald KA, Takeuchi O, Akira S, Tuschl T, Latz E, Ludwig J, Hartmann G. Schlee M, et al. Immunity. 2009 Jul 17;31(1):25-34. doi: 10.1016/j.immuni.2009.05.008. Epub 2009 Jul 2. Immunity. 2009. PMID: 19576794 Free PMC article.
112 results