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A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses.
Tan TK, Rijal P, Rahikainen R, Keeble AH, Schimanski L, Hussain S, Harvey R, Hayes JWP, Edwards JC, McLean RK, Martini V, Pedrera M, Thakur N, Conceicao C, Dietrich I, Shelton H, Ludi A, Wilsden G, Browning C, Zagrajek AK, Bialy D, Bhat S, Stevenson-Leggett P, Hollinghurst P, Tully M, Moffat K, Chiu C, Waters R, Gray A, Azhar M, Mioulet V, Newman J, Asfor AS, Burman A, Crossley S, Hammond JA, Tchilian E, Charleston B, Bailey D, Tuthill TJ, Graham SP, Duyvesteyn HME, Malinauskas T, Huo J, Tree JA, Buttigieg KR, Owens RJ, Carroll MW, Daniels RS, McCauley JW, Stuart DI, Huang KA, Howarth M, Townsend AR. Tan TK, et al. Among authors: schimanski l. Nat Commun. 2021 Jan 22;12(1):542. doi: 10.1038/s41467-020-20654-7. Nat Commun. 2021. PMID: 33483491 Free PMC article.
The hemochromatosis protein HFE inhibits iron export from macrophages.
Drakesmith H, Sweetland E, Schimanski L, Edwards J, Cowley D, Ashraf M, Bastin J, Townsend AR. Drakesmith H, et al. Among authors: schimanski l. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15602-7. doi: 10.1073/pnas.242614699. Epub 2002 Nov 12. Proc Natl Acad Sci U S A. 2002. PMID: 12429850 Free PMC article.
In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor.
Schimanski LM, Drakesmith H, Sweetland E, Bastin J, Rezgui D, Edelmann M, Kessler B, Merryweather-Clarke AT, Robson KJ, Townsend AR. Schimanski LM, et al. Blood Cells Mol Dis. 2009 Sep-Oct;43(2):180-93. doi: 10.1016/j.bcmd.2009.03.010. Epub 2009 May 31. Blood Cells Mol Dis. 2009. PMID: 19487139
Focused antibody response to influenza linked to antigenic drift.
Huang KY, Rijal P, Schimanski L, Powell TJ, Lin TY, McCauley JW, Daniels RS, Townsend AR. Huang KY, et al. Among authors: schimanski l. J Clin Invest. 2015 Jul 1;125(7):2631-45. doi: 10.1172/JCI81104. Epub 2015 May 26. J Clin Invest. 2015. PMID: 26011643 Free PMC article.
Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans.
Huang KA, Rijal P, Jiang H, Wang B, Schimanski L, Dong T, Liu YM, Chang P, Iqbal M, Wang MC, Chen Z, Song R, Huang CC, Yang JH, Qi J, Lin TY, Li A, Powell TJ, Jan JT, Ma C, Gao GF, Shi Y, Townsend AR. Huang KA, et al. Among authors: schimanski l. Nat Microbiol. 2019 Feb;4(2):306-315. doi: 10.1038/s41564-018-0303-7. Epub 2018 Nov 26. Nat Microbiol. 2019. PMID: 30478290
Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans.
Rijal P, Elias SC, Machado SR, Xiao J, Schimanski L, O'Dowd V, Baker T, Barry E, Mendelsohn SC, Cherry CJ, Jin J, Labbé GM, Donnellan FR, Rampling T, Dowall S, Rayner E, Findlay-Wilson S, Carroll M, Guo J, Xu XN, Huang KA, Takada A, Burgess G, McMillan D, Popplewell A, Lightwood DJ, Draper SJ, Townsend AR. Rijal P, et al. Among authors: schimanski l. Cell Rep. 2019 Apr 2;27(1):172-186.e7. doi: 10.1016/j.celrep.2019.03.020. Cell Rep. 2019. PMID: 30943399 Free article. Clinical Trial.
51 results