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Page 1
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages.
Wauters E, Van Mol P, Garg AD, Jansen S, Van Herck Y, Vanderbeke L, Bassez A, Boeckx B, Malengier-Devlies B, Timmerman A, Van Brussel T, Van Buyten T, Schepers R, Heylen E, Dauwe D, Dooms C, Gunst J, Hermans G, Meersseman P, Testelmans D, Yserbyt J, Tejpar S, De Wever W, Matthys P; CONTAGIOUS collaborators; Neyts J, Wauters J, Qian J, Lambrechts D. Wauters E, et al. Among authors: schepers r. Cell Res. 2021 Mar;31(3):272-290. doi: 10.1038/s41422-020-00455-9. Epub 2021 Jan 21. Cell Res. 2021. PMID: 33473155 Free PMC article.
Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis.
Franken A, Van Mol P, Vanmassenhove S, Donders E, Schepers R, Van Brussel T, Dooms C, Yserbyt J, De Crem N, Testelmans D, De Wever W, Nackaerts K, Vansteenkiste J, Vos R, Humblet-Baron S, Lambrechts D, Wauters E. Franken A, et al. Among authors: schepers r. J Immunother Cancer. 2022 Sep;10(9):e005323. doi: 10.1136/jitc-2022-005323. J Immunother Cancer. 2022. PMID: 36171010 Free PMC article.
CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation.
Fernández-García J, Franco F, Parik S, Altea-Manzano P, Pane AA, Broekaert D, van Elsen J, Di Conza G, Vermeire I, Schalley T, Planque M, van Brussel T, Schepers R, Modave E, Karakach TK, Carmeliet P, Lambrechts D, Ho PC, Fendt SM. Fernández-García J, et al. Among authors: schepers r. Cell Rep. 2022 Nov 15;41(7):111639. doi: 10.1016/j.celrep.2022.111639. Cell Rep. 2022. PMID: 36384124 Free article.
PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma.
Cappuyns S, Philips G, Vandecaveye V, Boeckx B, Schepers R, Van Brussel T, Arijs I, Mechels A, Bassez A, Lodi F, Jaekers J, Topal H, Topal B, Bricard O, Qian J, Van Cutsem E, Verslype C, Lambrechts D, Dekervel J. Cappuyns S, et al. Among authors: schepers r. Nat Commun. 2023 Nov 29;14(1):7825. doi: 10.1038/s41467-023-43381-1. Nat Commun. 2023. PMID: 38030622 Free PMC article.
Lower respiratory tract single-cell RNA sequencing and neutrophil extracellular trap profiling of COVID-19-associated pulmonary aspergillosis: a single centre, retrospective, observational study.
Feys S, Vanmassenhove S, Kraisin S, Yu K, Jacobs C, Boeckx B, Cambier S, Cunha C, Debaveye Y, Gonçalves SM, Hermans G, Humblet-Baron S, Jansen S, Lagrou K, Meersseman P, Neyts J, Peetermans M, Rocha-Pereira J, Schepers R, Spalart V, Starick MR, Thevissen K, Van Brussel T, Van Buyten T, Van Mol P, Vandenbriele C, Vanderbeke L, Wauters E, Wilmer A, Van Weyenbergh J, Van De Veerdonk FL, Carvalho A, Proost P, Martinod K, Lambrechts D, Wauters J. Feys S, et al. Among authors: schepers r. Lancet Microbe. 2024 Mar;5(3):e247-e260. doi: 10.1016/S2666-5247(23)00368-3. Epub 2024 Jan 24. Lancet Microbe. 2024. PMID: 38280387 Free article.
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy.
Franken A, Bila M, Mechels A, Kint S, Van Dessel J, Pomella V, Vanuytven S, Philips G, Bricard O, Xiong J, Boeckx B, Hatse S, Van Brussel T, Schepers R, Van Aerde C, Geurs S, Vandecaveye V, Hauben E, Vander Poorten V, Verbandt S, Vandereyken K, Qian J, Tejpar S, Voet T, Clement PM, Lambrechts D. Franken A, et al. Among authors: schepers r. Immunity. 2024 Mar 12;57(3):541-558.e7. doi: 10.1016/j.immuni.2024.02.007. Epub 2024 Mar 4. Immunity. 2024. PMID: 38442708
Transcriptomic characterization of the histopathological growth patterns in breast cancer liver metastases.
Leduc S, Nguyen HL, Richard F, Zels G, Mahdami A, De Schepper M, Maetens M, Pabba A, Jaekers J, Latacz E, Bohlok A, Vanderheyden E, Van Brussel T, Boeckx B, Schepers R, Lambrechts D, Dirix L, Larsimont D, Vankerckhove S, Lucidi V, Topal B, Bachir I, Donckier V, Floris G, Vermeulen P, Desmedt C. Leduc S, et al. Among authors: schepers r. Clin Exp Metastasis. 2024 Mar 29. doi: 10.1007/s10585-024-10279-1. Online ahead of print. Clin Exp Metastasis. 2024. PMID: 38548918
Rapid autopsies to enhance metastatic research: the UPTIDER post-mortem tissue donation program.
Geukens T, De Schepper M, Van Den Bogaert W, Van Baelen K, Maetens M, Pabba A, Mahdami A, Leduc S, Isnaldi E, Nguyen HL, Bachir I, Hajipirloo M, Zels G, Van Cauwenberge J, Borremans K, Vandecaveye V, Weynand B, Vermeulen P, Leucci E, Baietti MF, Sflomos G, Battista L, Brisken C, Derksen PWB, Koorman T, Visser D, Scheele CLGJ, Thommen DS, Hatse S, Fendt SM, Vanderheyden E, Van Brussel T, Schepers R, Boeckx B, Lambrechts D, Marano G, Biganzoli E, Smeets A, Nevelsteen I, Punie K, Neven P, Wildiers H, Richard F, Floris G, Desmedt C. Geukens T, et al. Among authors: schepers r. NPJ Breast Cancer. 2024 Apr 24;10(1):31. doi: 10.1038/s41523-024-00637-3. NPJ Breast Cancer. 2024. PMID: 38658604 Free PMC article.
Single-cell Atlas of Penile Cancer Reveals TP53 Mutations as a Driver of an Aggressive Phenotype, Irrespective of Human Papillomavirus Status, and Provides Clues for Treatment Personalization.
Elst L, Philips G, Vandermaesen K, Bassez A, Lodi F, Vreeburg MTA, Brouwer OR, Schepers R, Van Brussel T, Mohanty SK, Parwani AV, Spans L, Vanden Bempt I, Jacomen G, Baldewijns M, Lambrechts D, Albersen M. Elst L, et al. Among authors: schepers r. Eur Urol. 2024 Apr 25:S0302-2838(24)02266-8. doi: 10.1016/j.eururo.2024.03.038. Online ahead of print. Eur Urol. 2024. PMID: 38670879
PI3K/mTOR inhibition induces tumour microenvironment remodelling and sensitises pS6high uterine leiomyosarcoma to PD-1 blockade.
De Wispelaere W, Annibali D, Tuyaerts S, Messiaen J, Antoranz A, Shankar G, Dubroja N, Herreros-Pomares A, Baiden-Amissah REM, Orban MP, Delfini M, Berardi E, Van Brussel T, Schepers R, Philips G, Boeckx B, Baietti MF, Congedo L, HoWangYin KY, Bayon E, Van Rompuy AS, Leucci E, Tabruyn SP, Bosisio F, Mazzone M, Lambrechts D, Amant F. De Wispelaere W, et al. Among authors: schepers r. Clin Transl Med. 2024 May;14(5):e1655. doi: 10.1002/ctm2.1655. Clin Transl Med. 2024. PMID: 38711203 Free PMC article.
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