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Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses.
Jossi SE, Arcuri M, Alshayea A, Persaud RR, Marcial-Juárez E, Palmieri E, Di Benedetto R, Pérez-Toledo M, Pillaye J, Channell WM, Schager AE, Lamerton RE, Cook CN, Goodall M, Haneda T, Bäumler AJ, Jackson-Jones LH, Toellner KM, MacLennan CA, Henderson IR, Micoli F, Cunningham AF. Jossi SE, et al. Among authors: schager ae. Front Immunol. 2023 Mar 23;14:1139329. doi: 10.3389/fimmu.2023.1139329. eCollection 2023. Front Immunol. 2023. PMID: 37033932 Free PMC article.
IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates.
Schager AE, Dominguez-Medina CC, Necchi F, Micoli F, Goh YS, Goodall M, Flores-Langarica A, Bobat S, Cook CNL, Arcuri M, Marini A, King LDW, Morris FC, Anderson G, Toellner KM, Henderson IR, López-Macías C, MacLennan CA, Cunningham AF. Schager AE, et al. mBio. 2018 Mar 6;9(2):e02379-17. doi: 10.1128/mBio.02379-17. mBio. 2018. PMID: 29511082 Free PMC article.
IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD from Salmonella Typhimurium.
Zhang Y, Dominguez-Medina C, Cumley NJ, Heath JN, Essex SJ, Bobat S, Schager A, Goodall M, Kracker S, Buckley CD, May RC, Kingsley RA, MacLennan CA, López-Macías C, Cunningham AF, Toellner KM. Zhang Y, et al. J Immunol. 2017 Dec 15;199(12):4103-4109. doi: 10.4049/jimmunol.1700952. Epub 2017 Nov 10. J Immunol. 2017. PMID: 29127147 Free PMC article.
Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface.
Domínguez-Medina CC, Pérez-Toledo M, Schager AE, Marshall JL, Cook CN, Bobat S, Hwang H, Chun BJ, Logan E, Bryant JA, Channell WM, Morris FC, Jossi SE, Alshayea A, Rossiter AE, Barrow PA, Horsnell WG, MacLennan CA, Henderson IR, Lakey JH, Gumbart JC, López-Macías C, Bavro VN, Cunningham AF. Domínguez-Medina CC, et al. Among authors: schager ae. Nat Commun. 2020 Feb 12;11(1):851. doi: 10.1038/s41467-020-14655-9. Nat Commun. 2020. PMID: 32051408 Free PMC article.
YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium.
Morris FC, Wells TJ, Bryant JA, Schager AE, Sevastsyanovich YR, Squire DJP, Marshall J, Isom GL, Rooke J, Maderbocus R, Knowles TJ, Overduin M, Rossiter AE, Cunningham AF, Henderson IR. Morris FC, et al. Among authors: schager ae. Infect Immun. 2018 Oct 25;86(11):e00829-17. doi: 10.1128/IAI.00829-17. Print 2018 Nov. Infect Immun. 2018. PMID: 30201701 Free PMC article.
Role of a single noncoding nucleotide in the evolution of an epidemic African clade of Salmonella.
Hammarlöf DL, Kröger C, Owen SV, Canals R, Lacharme-Lora L, Wenner N, Schager AE, Wells TJ, Henderson IR, Wigley P, Hokamp K, Feasey NA, Gordon MA, Hinton JCD. Hammarlöf DL, et al. Among authors: schager ae. Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2614-E2623. doi: 10.1073/pnas.1714718115. Epub 2018 Feb 27. Proc Natl Acad Sci U S A. 2018. PMID: 29487214 Free PMC article.