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Inorganic phosphate exporter heterozygosity in mice leads to brain vascular calcification, microangiopathy, and microgliosis.
Maheshwari U, Mateos JM, Weber-Stadlbauer U, Ni R, Tamatey V, Sridhar S, Restrepo A, de Jong PA, Huang SF, Schaffenrath J, Stifter SA, Szeri F, Greter M, Koek HL, Keller A. Maheshwari U, et al. Among authors: schaffenrath j. Brain Pathol. 2023 Nov;33(6):e13189. doi: 10.1111/bpa.13189. Epub 2023 Jul 28. Brain Pathol. 2023. PMID: 37505935 Free PMC article.
Pericytes regulate vascular immune homeostasis in the CNS.
Török O, Schreiner B, Schaffenrath J, Tsai HC, Maheshwari U, Stifter SA, Welsh C, Amorim A, Sridhar S, Utz SG, Mildenberger W, Nassiri S, Delorenzi M, Aguzzi A, Han MH, Greter M, Becher B, Keller A. Török O, et al. Among authors: schaffenrath j. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2016587118. doi: 10.1073/pnas.2016587118. Proc Natl Acad Sci U S A. 2021. PMID: 33653955 Free PMC article.
Microglia control small vessel calcification via TREM2.
Zarb Y, Sridhar S, Nassiri S, Utz SG, Schaffenrath J, Maheshwari U, Rushing EJ, Nilsson KPR, Delorenzi M, Colonna M, Greter M, Keller A. Zarb Y, et al. Among authors: schaffenrath j. Sci Adv. 2021 Feb 26;7(9):eabc4898. doi: 10.1126/sciadv.abc4898. Print 2021 Feb. Sci Adv. 2021. PMID: 33637522 Free PMC article.
Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity.
Veys K, Fan Z, Ghobrial M, Bouché A, García-Caballero M, Vriens K, Conchinha NV, Seuwen A, Schlegel F, Gorski T, Crabbé M, Gilardoni P, Ardicoglu R, Schaffenrath J, Casteels C, De Smet G, Smolders I, Van Laere K, Abel ED, Fendt SM, Schroeter A, Kalucka J, Cantelmo AR, Wälchli T, Keller A, Carmeliet P, De Bock K. Veys K, et al. Among authors: schaffenrath j. Circ Res. 2020 Jul 31;127(4):466-482. doi: 10.1161/CIRCRESAHA.119.316463. Epub 2020 May 14. Circ Res. 2020. PMID: 32404031 Free PMC article.