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5-Chlorothiophene-2-carboxylic acid [(S)-2-[2-methyl-3-(2-oxopyrrolidin-1-yl)benzenesulfonylamino]-3-(4-methylpiperazin-1-yl)-3-oxopropyl]amide (SAR107375), a selective and potent orally active dual thrombin and factor Xa inhibitor.
Meneyrol J, Follmann M, Lassalle G, Wehner V, Barre G, Rousseaux T, Altenburger JM, Petit F, Bocskei Z, Schreuder H, Alet N, Herault JP, Millet L, Dol F, Florian P, Schaeffer P, Sadoun F, Klieber S, Briot C, Bono F, Herbert JM. Meneyrol J, et al. Among authors: schaeffer p. J Med Chem. 2013 Dec 12;56(23):9441-56. doi: 10.1021/jm4005835. Epub 2013 Dec 3. J Med Chem. 2013. PMID: 24175584
SSR182289A, a selective and potent orally active thrombin inhibitor.
Altenburger JM, Lassalle GY, Matrougui M, Galtier D, Jetha JC, Bocskei Z, Berry CN, Lunven C, Lorrain J, Herault JP, Schaeffer P, O'Connor SE, Herbert JM. Altenburger JM, et al. Among authors: schaeffer p. Bioorg Med Chem. 2004 Apr 1;12(7):1713-30. doi: 10.1016/j.bmc.2004.01.016. Bioorg Med Chem. 2004. PMID: 15028263
SR123781A, a synthetic heparin mimetic.
Herbert JM, Hérault JP, Bernat A, Savi P, Schaeffer P, Driguez PA, Duchaussoy P, Petitou M. Herbert JM, et al. Among authors: schaeffer p. Thromb Haemost. 2001 May;85(5):852-60. Thromb Haemost. 2001. PMID: 11372679
Pharmacokinetics of new synthetic heparin mimetics.
Hérault JP, Bernat A, Roye F, Michaux C, Schaeffer P, Bono F, Petitou M, Herbert JM. Hérault JP, et al. Among authors: schaeffer p. Thromb Haemost. 2002 Jun;87(6):985-9. Thromb Haemost. 2002. PMID: 12083506
277 results