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Type I Interferon Signaling Disrupts the Hepatic Urea Cycle and Alters Systemic Metabolism to Suppress T Cell Function.
Lercher A, Bhattacharya A, Popa AM, Caldera M, Schlapansky MF, Baazim H, Agerer B, Gürtl B, Kosack L, Májek P, Brunner JS, Vitko D, Pinter T, Genger JW, Orlova A, Pikor N, Reil D, Ozsvár-Kozma M, Kalinke U, Ludewig B, Moriggl R, Bennett KL, Menche J, Cheng PN, Schabbauer G, Trauner M, Klavins K, Bergthaler A. Lercher A, et al. Among authors: schabbauer g. Immunity. 2019 Dec 17;51(6):1074-1087.e9. doi: 10.1016/j.immuni.2019.10.014. Epub 2019 Nov 26. Immunity. 2019. PMID: 31784108 Free PMC article.
Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.
Sahin E, Haubenwallner S, Kuttke M, Kollmann I, Halfmann A, Dohnal AM, Chen L, Cheng P, Hoesel B, Einwallner E, Brunner J, Kral JB, Schrottmaier WC, Thell K, Saferding V, Blüml S, Schabbauer G. Sahin E, et al. Among authors: schabbauer g. J Immunol. 2014 Aug 15;193(4):1717-27. doi: 10.4049/jimmunol.1302167. Epub 2014 Jul 11. J Immunol. 2014. PMID: 25015834 Free PMC article.
Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis.
Blüml S, Sahin E, Saferding V, Goncalves-Alves E, Hainzl E, Niederreiter B, Hladik A, Lohmeyer T, Brunner JS, Bonelli M, Koenders MI, van den Berg WB, Superti-Furga G, Smolen JS, Schabbauer G, Redlich K. Blüml S, et al. Among authors: schabbauer g. Arthritis Res Ther. 2015 Aug 26;17(1):230. doi: 10.1186/s13075-015-0742-y. Arthritis Res Ther. 2015. PMID: 26307404 Free PMC article.
Macrophage Rewiring by Nutrient Associated PI3K Dependent Pathways.
Sharif O, Brunner JS, Vogel A, Schabbauer G. Sharif O, et al. Among authors: schabbauer g. Front Immunol. 2019 Aug 21;10:2002. doi: 10.3389/fimmu.2019.02002. eCollection 2019. Front Immunol. 2019. PMID: 31497027 Free PMC article. Review.
Environmental arginine controls multinuclear giant cell metabolism and formation.
Brunner JS, Vulliard L, Hofmann M, Kieler M, Lercher A, Vogel A, Russier M, Brüggenthies JB, Kerndl M, Saferding V, Niederreiter B, Junza A, Frauenstein A, Scholtysek C, Mikami Y, Klavins K, Krönke G, Bergthaler A, O'Shea JJ, Weichhart T, Meissner F, Smolen JS, Cheng P, Yanes O, Menche J, Murray PJ, Sharif O, Blüml S, Schabbauer G. Brunner JS, et al. Among authors: schabbauer g. Nat Commun. 2020 Jan 22;11(1):431. doi: 10.1038/s41467-020-14285-1. Nat Commun. 2020. PMID: 31969567 Free PMC article.
The PI3K pathway preserves metabolic health through MARCO-dependent lipid uptake by adipose tissue macrophages.
Brunner JS, Vogel A, Lercher A, Caldera M, Korosec A, Pühringer M, Hofmann M, Hajto A, Kieler M, Garrido LQ, Kerndl M, Kuttke M, Mesteri I, Górna MW, Kulik M, Dominiak PM, Brandon AE, Estevez E, Egan CL, Gruber F, Schweiger M, Menche J, Bergthaler A, Weichhart T, Klavins K, Febbraio MA, Sharif O, Schabbauer G. Brunner JS, et al. Among authors: schabbauer g. Nat Metab. 2020 Dec;2(12):1427-1442. doi: 10.1038/s42255-020-00311-5. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199895
Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages.
Sharif O, Brunner JS, Korosec A, Martins R, Jais A, Snijder B, Vogel A, Caldera M, Hladik A, Lakovits K, Saluzzo S, Boehm B, Gorki AD, Mesteri I, Lindroos-Christensen J, Tillmann K, Stoiber D, Menche J, Schabbauer G, Bilban M, Superti-Furga G, Esterbauer H, Knapp S. Sharif O, et al. Among authors: schabbauer g. Diabetes. 2021 Sep;70(9):2042-2057. doi: 10.2337/db20-0572. Epub 2021 Feb 24. Diabetes. 2021. PMID: 33627323 Free PMC article.
81 results